tetano
Editor, Senior Moderator
Indian J Crit Care Med. 2019 Jun;23(6):263-269. doi: 10.5005/jp-journals-10071-23177.
[h=1]Comprehensive Analysis of Severe Viral Infections of Respiratory Tract admitted to PICUs during the Winter Season in Turkey.[/h] Kockuzu E[SUP]1[/SUP], Bayrakcı B[SUP]1[/SUP], Kesici S[SUP]2[/SUP], Cıtak A[SUP]3[/SUP], Karapınar B[SUP]4[/SUP], Emeksiz S[SUP]5[/SUP], Anıl AB[SUP]6[/SUP], Kendirli T[SUP]7[/SUP], Yukselmis U[SUP]8[/SUP], Sevketoglu E[SUP]9[/SUP], Paksu Ş[SUP]10[/SUP], Kutlu O[SUP]11[/SUP], Agın H[SUP]12[/SUP], Yıldızdas D[SUP]13[/SUP], Keskin H[SUP]14[/SUP], Kalkan G[SUP]15[/SUP], Hasanoglu A[SUP]16[/SUP], Yazıcı MU[SUP]1[/SUP], Sık G[SUP]2[/SUP], Kılınc A[SUP]4[/SUP], Durak F[SUP]4[/SUP], Perk O[SUP]7[/SUP], Talip M[SUP]9[/SUP], Yener N[SUP]10[/SUP], Uzuner S[SUP]11[/SUP].
[h=3]Author information[/h] 1 Department of Pediatric Intensive Care Unit, Hacettepe University Faculty of Medicine, Ankara, Turkey. 2 Clinic of Pediatric Intensive Care Unit, Dr. Sami Ulus Child Health and Disease Training and Research Hospital, Ankara, Turkey. 3 Department of Pediatric Intensive Care Unit, Acıbadem University Faculty of Medicine, Istanbul, Turkey. 4 Department of Pediatric Intensive Care Unit, Ege University Faculty of Medicine, Izmir, Turkey. 5 Clinic of Pediatric Intensive Care Unit, Ankara Pediatric Hematology Oncology Training and Research Hospital, Ankara, Turkey. 6 Clinic of Pediatric Intensive Care Unit, Ankara Tepecik Training and Research Hospital, Izmir, Turkey. 7 Department of Pediatric Intensive Care Unit, Ankara University Faculty of Medicine, Ankara, Turkey. 8 Clinic of Pediatric Intensive Care Unit, Kartal Lutfi Kırdar Education Research Hospital, Istanbul, Turkey. 9 Clinic of Pediatric Intensive Care Unit, Bakırkoy Sadi Konuk Education Research Hospital, Istanbul, Turkey. 10 Department of Pediatric Intensive Care Unit, Ondokuz Mayıs University, Faculty of Medicine, Samsun, Turkey. 11 Department of Pediatric Intensive Care Unit, Bezmialem University Faculty of Medicine, Istanbul, Turkey. 12 Clinic of Pediatric Intensive Care Unit Dr. Behcet Uz Education Research Hospital, Izmir, Turkey. 13 Department of Pediatric Intensive Care Unit, Cukurova University Faculty of Medicine, Adana, Turkey. 14 Department of Pediatric Intensive Care Unit, Ataturk University Faculty of Medicine, Erzurum, Turkey. 15 Department of Pediatric Intensive Care Unit, Gazi University Faculty of Medicine, Ankara, Turkey. 16 Department of Pediatric Intensive Care Unit, Gaziantep University Faculty of Medicine, Gaziantep, Turkey.
[h=3]Abstract[/h] [h=4]Objectives:[/h] To analyze the course of seasonal viral infections of respiratory tract in patients hospitalized in pediatric intensive care units (PICU) of 16 centers in Turkey.
[h=4]Materials and methods:[/h] It is a retrospective, observational, and multicenter study conducted in 16 tertiary PICUs in Turkey includes a total of 302 children with viral cause in the nasal swab which required PICU admission with no interventions.
[h=4]Results:[/h] Median age of patients was 12 months. Respiratory syncytial virus (RSV) was more common in patients over one year of age whereas influenza, human Bocavirus in patients above a year of age was more common (p <0.05). Clinical presentations influencing mortality were neurologic symptoms, tachycardia, hypoxia, hypotension, elevated lactate, and acidosis. The critical pH value related with mortality was ≤7.10, and critical PCO[SUB]2[/SUB] ≥60 mm Hg.
[h=4]Conclusion:[/h] Our findings demonstrate that patients with neurological symptoms, tachycardia, hypoxia, hypotension, acidosis, impaired liver, and renal function at the time of admission exhibit more severe mortal progressions. Presence of acidosis and multiorgan failure was found to be predictor for mortality. Knowledge of clinical presentation and age-related variations among seasonal viruses may give a clue about severe course and prognosis. By presenting the analyzed data of 302 PICU admissions, current study reveals severity of viral respiratory tract infections and release tips for handling them.
[h=4]How to cite this article:[/h] Kockuzu E, Bayrakcı B, Kesici S, Cıtak A, Karapınar K, Emeksiz S, et al. Comprehensive Analysis of Severe Viral Infections of Respiratory Tract admitted to PICUs During the Winter Season in Turkey. Indian J Crit Care Med 2019;23(6):263-269.
[h=4]KEYWORDS:[/h] Mortality; Multiorgan failure; Pediatric intensive care unit; Seasonal; Viruses
PMID: 31435144 PMCID: PMC6698354 DOI: 10.5005/jp-journals-10071-23177
[h=1]Comprehensive Analysis of Severe Viral Infections of Respiratory Tract admitted to PICUs during the Winter Season in Turkey.[/h] Kockuzu E[SUP]1[/SUP], Bayrakcı B[SUP]1[/SUP], Kesici S[SUP]2[/SUP], Cıtak A[SUP]3[/SUP], Karapınar B[SUP]4[/SUP], Emeksiz S[SUP]5[/SUP], Anıl AB[SUP]6[/SUP], Kendirli T[SUP]7[/SUP], Yukselmis U[SUP]8[/SUP], Sevketoglu E[SUP]9[/SUP], Paksu Ş[SUP]10[/SUP], Kutlu O[SUP]11[/SUP], Agın H[SUP]12[/SUP], Yıldızdas D[SUP]13[/SUP], Keskin H[SUP]14[/SUP], Kalkan G[SUP]15[/SUP], Hasanoglu A[SUP]16[/SUP], Yazıcı MU[SUP]1[/SUP], Sık G[SUP]2[/SUP], Kılınc A[SUP]4[/SUP], Durak F[SUP]4[/SUP], Perk O[SUP]7[/SUP], Talip M[SUP]9[/SUP], Yener N[SUP]10[/SUP], Uzuner S[SUP]11[/SUP].
[h=3]Author information[/h] 1 Department of Pediatric Intensive Care Unit, Hacettepe University Faculty of Medicine, Ankara, Turkey. 2 Clinic of Pediatric Intensive Care Unit, Dr. Sami Ulus Child Health and Disease Training and Research Hospital, Ankara, Turkey. 3 Department of Pediatric Intensive Care Unit, Acıbadem University Faculty of Medicine, Istanbul, Turkey. 4 Department of Pediatric Intensive Care Unit, Ege University Faculty of Medicine, Izmir, Turkey. 5 Clinic of Pediatric Intensive Care Unit, Ankara Pediatric Hematology Oncology Training and Research Hospital, Ankara, Turkey. 6 Clinic of Pediatric Intensive Care Unit, Ankara Tepecik Training and Research Hospital, Izmir, Turkey. 7 Department of Pediatric Intensive Care Unit, Ankara University Faculty of Medicine, Ankara, Turkey. 8 Clinic of Pediatric Intensive Care Unit, Kartal Lutfi Kırdar Education Research Hospital, Istanbul, Turkey. 9 Clinic of Pediatric Intensive Care Unit, Bakırkoy Sadi Konuk Education Research Hospital, Istanbul, Turkey. 10 Department of Pediatric Intensive Care Unit, Ondokuz Mayıs University, Faculty of Medicine, Samsun, Turkey. 11 Department of Pediatric Intensive Care Unit, Bezmialem University Faculty of Medicine, Istanbul, Turkey. 12 Clinic of Pediatric Intensive Care Unit Dr. Behcet Uz Education Research Hospital, Izmir, Turkey. 13 Department of Pediatric Intensive Care Unit, Cukurova University Faculty of Medicine, Adana, Turkey. 14 Department of Pediatric Intensive Care Unit, Ataturk University Faculty of Medicine, Erzurum, Turkey. 15 Department of Pediatric Intensive Care Unit, Gazi University Faculty of Medicine, Ankara, Turkey. 16 Department of Pediatric Intensive Care Unit, Gaziantep University Faculty of Medicine, Gaziantep, Turkey.
[h=3]Abstract[/h] [h=4]Objectives:[/h] To analyze the course of seasonal viral infections of respiratory tract in patients hospitalized in pediatric intensive care units (PICU) of 16 centers in Turkey.
[h=4]Materials and methods:[/h] It is a retrospective, observational, and multicenter study conducted in 16 tertiary PICUs in Turkey includes a total of 302 children with viral cause in the nasal swab which required PICU admission with no interventions.
[h=4]Results:[/h] Median age of patients was 12 months. Respiratory syncytial virus (RSV) was more common in patients over one year of age whereas influenza, human Bocavirus in patients above a year of age was more common (p <0.05). Clinical presentations influencing mortality were neurologic symptoms, tachycardia, hypoxia, hypotension, elevated lactate, and acidosis. The critical pH value related with mortality was ≤7.10, and critical PCO[SUB]2[/SUB] ≥60 mm Hg.
[h=4]Conclusion:[/h] Our findings demonstrate that patients with neurological symptoms, tachycardia, hypoxia, hypotension, acidosis, impaired liver, and renal function at the time of admission exhibit more severe mortal progressions. Presence of acidosis and multiorgan failure was found to be predictor for mortality. Knowledge of clinical presentation and age-related variations among seasonal viruses may give a clue about severe course and prognosis. By presenting the analyzed data of 302 PICU admissions, current study reveals severity of viral respiratory tract infections and release tips for handling them.
[h=4]How to cite this article:[/h] Kockuzu E, Bayrakcı B, Kesici S, Cıtak A, Karapınar K, Emeksiz S, et al. Comprehensive Analysis of Severe Viral Infections of Respiratory Tract admitted to PICUs During the Winter Season in Turkey. Indian J Crit Care Med 2019;23(6):263-269.
[h=4]KEYWORDS:[/h] Mortality; Multiorgan failure; Pediatric intensive care unit; Seasonal; Viruses
PMID: 31435144 PMCID: PMC6698354 DOI: 10.5005/jp-journals-10071-23177