tetano
Editor, Senior Moderator
Comput Math Methods Med
. 2020 Sep 1;2020:1352982.
doi: 10.1155/2020/1352982. eCollection 2020.
A Model for SARS-CoV-2 Infection with Treatment
Amar Nath Chatterjee[SUP] 1 [/SUP], Fahad Al Basir[SUP] 2 [/SUP]
Affiliations
Abstract
The current emergence of coronavirus (SARS-CoV-2) puts the world in threat. The structural research on the receptor recognition by SARS-CoV-2 has identified the key interactions between SARS-CoV-2 spike protein and its host (epithelial cell) receptor, also known as angiotensin-converting enzyme 2 (ACE2). It controls both the cross-species and human-to-human transmissions of SARS-CoV-2. In view of this, we propose and analyze a mathematical model for investigating the effect of CTL responses over the viral mutation to control the viral infection when a postinfection immunostimulant drug (pidotimod) is administered at regular intervals. Dynamics of the system with and without impulses have been analyzed using the basic reproduction number. This study shows that the proper dosing interval and drug dose both are important to eradicate the viral infection.
. 2020 Sep 1;2020:1352982.
doi: 10.1155/2020/1352982. eCollection 2020.
A Model for SARS-CoV-2 Infection with Treatment
Amar Nath Chatterjee[SUP] 1 [/SUP], Fahad Al Basir[SUP] 2 [/SUP]
Affiliations
- PMID: 32908574
- PMCID: PMC7463400
- DOI: 10.1155/2020/1352982
Abstract
The current emergence of coronavirus (SARS-CoV-2) puts the world in threat. The structural research on the receptor recognition by SARS-CoV-2 has identified the key interactions between SARS-CoV-2 spike protein and its host (epithelial cell) receptor, also known as angiotensin-converting enzyme 2 (ACE2). It controls both the cross-species and human-to-human transmissions of SARS-CoV-2. In view of this, we propose and analyze a mathematical model for investigating the effect of CTL responses over the viral mutation to control the viral infection when a postinfection immunostimulant drug (pidotimod) is administered at regular intervals. Dynamics of the system with and without impulses have been analyzed using the basic reproduction number. This study shows that the proper dosing interval and drug dose both are important to eradicate the viral infection.