tetano
Editor, Senior Moderator
Comput Struct Biotechnol J
. 2021 Jul 26.
doi: 10.1016/j.csbj.2021.07.023. Online ahead of print.
Immune evasion of SARS-CoV-2 from interferon antiviral system
Yuan-Qin Min[SUP] 1 2 [/SUP], Mengzhuo Huang[SUP] 1 3 [/SUP], Xiulian Sun[SUP] 1 2 [/SUP], Fei Deng[SUP] 1 2 [/SUP], Hualin Wang[SUP] 1 2 [/SUP], Yun-Jia Ning[SUP] 1 2 [/SUP]
Affiliations
Abstract
The on-going pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to unprecedented medical and socioeconomic crises. Although the viral pathogenesis remains elusive, deficiency of effective antiviral interferon (IFN) responses upon SARS-CoV-2 infection has been recognized as a hallmark of COVID-19 contributing to the disease pathology and progress. Recently, multiple proteins encoded by SARS-CoV-2 have been shown to act as potential IFN antagonists with diverse possible mechanisms. Here, we summarize and discuss the strategies of SARS-CoV-2 for evasion of innate immunity (particularly the antiviral IFN responses), understanding of which will facilitate not only the elucidation of SARS-CoV-2 infection and pathogenesis but also the development of antiviral intervention therapies.
Keywords: COVID-19; SARS-CoV-2; coronavirus; immune evasion; innate immunity; interferon.
. 2021 Jul 26.
doi: 10.1016/j.csbj.2021.07.023. Online ahead of print.
Immune evasion of SARS-CoV-2 from interferon antiviral system
Yuan-Qin Min[SUP] 1 2 [/SUP], Mengzhuo Huang[SUP] 1 3 [/SUP], Xiulian Sun[SUP] 1 2 [/SUP], Fei Deng[SUP] 1 2 [/SUP], Hualin Wang[SUP] 1 2 [/SUP], Yun-Jia Ning[SUP] 1 2 [/SUP]
Affiliations
- PMID: 34336145
- PMCID: PMC8310780
- DOI: 10.1016/j.csbj.2021.07.023
Abstract
The on-going pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to unprecedented medical and socioeconomic crises. Although the viral pathogenesis remains elusive, deficiency of effective antiviral interferon (IFN) responses upon SARS-CoV-2 infection has been recognized as a hallmark of COVID-19 contributing to the disease pathology and progress. Recently, multiple proteins encoded by SARS-CoV-2 have been shown to act as potential IFN antagonists with diverse possible mechanisms. Here, we summarize and discuss the strategies of SARS-CoV-2 for evasion of innate immunity (particularly the antiviral IFN responses), understanding of which will facilitate not only the elucidation of SARS-CoV-2 infection and pathogenesis but also the development of antiviral intervention therapies.
Keywords: COVID-19; SARS-CoV-2; coronavirus; immune evasion; innate immunity; interferon.