tetano
Editor, Senior Moderator
Vaccine. 2010 Oct 5. [Epub ahead of print]
Contrasting substitution patterns between HA proteins of avian and human influenza viruses: Implication for monitoring human influenza epidemics.
Liao YC, Chen FC, Hsiung CA.
Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Zhunan 350, Taiwan.
Abstract
The HA1 domain of influenza A viruses is critical for immune escape and host receptor recognition. However, the association between HA1 evolution and host species-specific adaptations remains unclear. We have identified the amino acid sites that are related to the host species-specific adaptations by systematically comparing the evolutionary dynamics of HA1 between human and avian hosts for both H1N1 and H3N2 viruses. We can thus refine the "positively selected sites" in the HA1 domain of these two virus subtypes to those that occur only in humans. We further demonstrate that the refined sets can accurately reflect influenza epidemics. Our retrospective study shows that when substitutions occur at more than three out of these identified sites in the same year, an epidemic is very likely to occur. Therefore, our approach could potentially be used in determining whether new influenza vaccines are needed.
PMID: 20933040 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20933040
Contrasting substitution patterns between HA proteins of avian and human influenza viruses: Implication for monitoring human influenza epidemics.
Liao YC, Chen FC, Hsiung CA.
Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Zhunan 350, Taiwan.
Abstract
The HA1 domain of influenza A viruses is critical for immune escape and host receptor recognition. However, the association between HA1 evolution and host species-specific adaptations remains unclear. We have identified the amino acid sites that are related to the host species-specific adaptations by systematically comparing the evolutionary dynamics of HA1 between human and avian hosts for both H1N1 and H3N2 viruses. We can thus refine the "positively selected sites" in the HA1 domain of these two virus subtypes to those that occur only in humans. We further demonstrate that the refined sets can accurately reflect influenza epidemics. Our retrospective study shows that when substitutions occur at more than three out of these identified sites in the same year, an epidemic is very likely to occur. Therefore, our approach could potentially be used in determining whether new influenza vaccines are needed.
PMID: 20933040 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20933040