tetano
Editor, Senior Moderator
Influenza Other Respir Viruses. 2016 Jun 17. doi: 10.1111/irv.12400. [Epub ahead of print]
[h=1]Contribution of Influenza Viruses to Medically-Attended Acute Respiratory Illnesses in Children in High-Income Countries: A Meta-Analysis.[/h] Buchan SA[SUP]1[/SUP], Hottes TS[SUP]1[/SUP], Rosella LC[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Crowcroft NS, Tran D[SUP]4[/SUP], Kwong JC[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3,[/SUP][SUP]5,[/SUP][SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]AIM:[/h] The burden of disease in children attributable to influenza viruses is difficult to quantify given the similarity of symptoms caused by infection due to influenza and other viruses. This uncertainty impacts clinical decision-making and estimates of burden. We aimed to systematically review the literature to determine the proportion of healthy children presenting for healthcare with an acute respiratory illness who have laboratory-confirmed seasonal influenza (PROSPERO ID#CRD42014013896).
[h=4]METHOD:[/h] We searched OVID MEDLINE, EMBASE, Scopus, and references of included articles. We included studies that used polymerase chain reaction methods to test for influenza in healthy children aged ≤5 years who presented for healthcare in high-income countries with an influenza-like or acute respiratory illness. A standardized form was used to collect data on positivity and other relevant study elements.
[h=4]RESULTS:[/h] Seventeen studies covering 12 different influenza seasons were included. The proportion of influenza positivity ranged from 11% to 56%. Subgroup analyses were performed by influenza season, continent, healthcare setting, age group, and vaccination status. Higher influenza positivity was reported among children aged 3-5 years compared to children aged ≤2 years, and for unvaccinated children.
[h=4]CONCLUSION:[/h] The minority of healthy patients aged ≤5 years with medically-attended influenza-like or acute respiratory symptoms have laboratory-confirmed influenza virus infection, although this varied by influenza season. Prevention efforts should be targeted accordingly. Statement: Most influenza-like illnesses are not laboratory-confirmed and have similar clinical presentations. Consequently, the true contribution of influenza to acute respiratory infections in children remains uncertain. Our systematic review estimates that this proportion ranges from 11% to 56%. This finding can help both clinicians and public health professionals target prevention. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Acute Respiratory Illness; Child; Human; Influenza; Meta-Analysis; Polymerase Chain Reaction
PMID: 27311404 [PubMed - as supplied by publisher] Free full text
[h=1]Contribution of Influenza Viruses to Medically-Attended Acute Respiratory Illnesses in Children in High-Income Countries: A Meta-Analysis.[/h] Buchan SA[SUP]1[/SUP], Hottes TS[SUP]1[/SUP], Rosella LC[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Crowcroft NS, Tran D[SUP]4[/SUP], Kwong JC[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3,[/SUP][SUP]5,[/SUP][SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]AIM:[/h] The burden of disease in children attributable to influenza viruses is difficult to quantify given the similarity of symptoms caused by infection due to influenza and other viruses. This uncertainty impacts clinical decision-making and estimates of burden. We aimed to systematically review the literature to determine the proportion of healthy children presenting for healthcare with an acute respiratory illness who have laboratory-confirmed seasonal influenza (PROSPERO ID#CRD42014013896).
[h=4]METHOD:[/h] We searched OVID MEDLINE, EMBASE, Scopus, and references of included articles. We included studies that used polymerase chain reaction methods to test for influenza in healthy children aged ≤5 years who presented for healthcare in high-income countries with an influenza-like or acute respiratory illness. A standardized form was used to collect data on positivity and other relevant study elements.
[h=4]RESULTS:[/h] Seventeen studies covering 12 different influenza seasons were included. The proportion of influenza positivity ranged from 11% to 56%. Subgroup analyses were performed by influenza season, continent, healthcare setting, age group, and vaccination status. Higher influenza positivity was reported among children aged 3-5 years compared to children aged ≤2 years, and for unvaccinated children.
[h=4]CONCLUSION:[/h] The minority of healthy patients aged ≤5 years with medically-attended influenza-like or acute respiratory symptoms have laboratory-confirmed influenza virus infection, although this varied by influenza season. Prevention efforts should be targeted accordingly. Statement: Most influenza-like illnesses are not laboratory-confirmed and have similar clinical presentations. Consequently, the true contribution of influenza to acute respiratory infections in children remains uncertain. Our systematic review estimates that this proportion ranges from 11% to 56%. This finding can help both clinicians and public health professionals target prevention. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Acute Respiratory Illness; Child; Human; Influenza; Meta-Analysis; Polymerase Chain Reaction
PMID: 27311404 [PubMed - as supplied by publisher] Free full text