tetano
Editor, Senior Moderator
Vaccine. 2016 May 5. pii: S0264-410X(16)30211-0. doi: 10.1016/j.vaccine.2016.04.057. [Epub ahead of print]
[h=1]Cost-effectiveness of seasonal inactivated influenza vaccination among pregnant women.[/h] Xu J[SUP]1[/SUP], Zhou F[SUP]2[/SUP], Reed C[SUP]3[/SUP], Chaves SS[SUP]4[/SUP], Messonnier M[SUP]5[/SUP], Kim IK[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVE:[/h] To evaluate the cost-effectiveness of seasonal inactivated influenza vaccination among pregnant women using data from three recent influenza seasons in the United States.
[h=4]DESIGN, SETTING, AND PARTICIPANTS:[/h] We developed a decision-analytic model following a cohort of 5.2 million pregnant women and their infants aged <6 months to evaluate the cost-effectiveness of vaccinating women against seasonal influenza during pregnancy from a societal perspective. The main outcome measures were quality-adjusted life-year (QALY) gained and cost-effectiveness ratios. Data sources included surveillance data, epidemiological studies, and published vaccine cost data. Sensitivity analyses were also performed. All costs and outcomes were discounted at 3% annually.
[h=4]MAIN OUTCOME MEASURES:[/h] Total costs (direct and indirect), effects (QALY gains, averted case numbers), and incremental cost-effectiveness of seasonal inactivated influenza vaccination among pregnant women (cost per QALY gained).
[h=4]RESULTS:[/h] Using a recent benchmark of 52.2% vaccination coverage among pregnant women, we studied a hypothetical cohort of 2,753,015 vaccinated pregnant women. With an estimated vaccine effectiveness of 73% among pregnant women and 63% among infants <6 months, QALY gains for each season were 305 (2010-2011), 123 (2011-2012), and 610 (2012-2013). Compared with no vaccination, seasonal influenza vaccination during pregnancy was cost-saving when using data from the 2010-2011 and 2012-2013 influenza seasons. The cost-effectiveness ratio was greater than $100,000/QALY with the 2011-2012 influenza season data, when CDC reported a low attack rate compared to other recent seasons.
[h=4]CONCLUSIONS:[/h] Influenza vaccination for pregnant women can reduce morbidity from influenza in both pregnant women and their infants aged <6 months. Seasonal influenza vaccination during pregnancy is cost-saving during moderate to severe influenza seasons.
Copyright ? 2016 Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] Cost-effectiveness analysis; Pregnancy; Seasonal influenza vaccination
PMID: 27161997 [PubMed - as supplied by publisher]
[h=1]Cost-effectiveness of seasonal inactivated influenza vaccination among pregnant women.[/h] Xu J[SUP]1[/SUP], Zhou F[SUP]2[/SUP], Reed C[SUP]3[/SUP], Chaves SS[SUP]4[/SUP], Messonnier M[SUP]5[/SUP], Kim IK[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVE:[/h] To evaluate the cost-effectiveness of seasonal inactivated influenza vaccination among pregnant women using data from three recent influenza seasons in the United States.
[h=4]DESIGN, SETTING, AND PARTICIPANTS:[/h] We developed a decision-analytic model following a cohort of 5.2 million pregnant women and their infants aged <6 months to evaluate the cost-effectiveness of vaccinating women against seasonal influenza during pregnancy from a societal perspective. The main outcome measures were quality-adjusted life-year (QALY) gained and cost-effectiveness ratios. Data sources included surveillance data, epidemiological studies, and published vaccine cost data. Sensitivity analyses were also performed. All costs and outcomes were discounted at 3% annually.
[h=4]MAIN OUTCOME MEASURES:[/h] Total costs (direct and indirect), effects (QALY gains, averted case numbers), and incremental cost-effectiveness of seasonal inactivated influenza vaccination among pregnant women (cost per QALY gained).
[h=4]RESULTS:[/h] Using a recent benchmark of 52.2% vaccination coverage among pregnant women, we studied a hypothetical cohort of 2,753,015 vaccinated pregnant women. With an estimated vaccine effectiveness of 73% among pregnant women and 63% among infants <6 months, QALY gains for each season were 305 (2010-2011), 123 (2011-2012), and 610 (2012-2013). Compared with no vaccination, seasonal influenza vaccination during pregnancy was cost-saving when using data from the 2010-2011 and 2012-2013 influenza seasons. The cost-effectiveness ratio was greater than $100,000/QALY with the 2011-2012 influenza season data, when CDC reported a low attack rate compared to other recent seasons.
[h=4]CONCLUSIONS:[/h] Influenza vaccination for pregnant women can reduce morbidity from influenza in both pregnant women and their infants aged <6 months. Seasonal influenza vaccination during pregnancy is cost-saving during moderate to severe influenza seasons.
Copyright ? 2016 Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] Cost-effectiveness analysis; Pregnancy; Seasonal influenza vaccination
PMID: 27161997 [PubMed - as supplied by publisher]