tetano
Editor, Senior Moderator
Crit Care
. 2021 Jul 12;25(1):244.
doi: 10.1186/s13054-021-03662-x.
Emerging SARS-CoV-2 variants of concern and potential intervention approaches
Jasmin Khateeb[SUP] 1 2 [/SUP], Yuchong Li[SUP] 1 3 [/SUP], Haibo Zhang[SUP] 4 5 6 [/SUP]
Affiliations
Abstract
The major variant of concerns (VOCs) have shared mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike proteins, mostly on the S1 unit and resulted in higher transmissibility rate and affect viral virulence and clinical outcome. The spike protein mutations and other non-structural protein mutations in the VOCs may lead to escape approved vaccinations in certain extend. We will discuss these VOC mutations and discuss the need for combination therapeutic strategies targeting viral cycle and immune host responses.
Keywords: B.1.1.7; B.1.351; P.1. B.1617.1; Transmissibility; Viral virulence.
. 2021 Jul 12;25(1):244.
doi: 10.1186/s13054-021-03662-x.
Emerging SARS-CoV-2 variants of concern and potential intervention approaches
Jasmin Khateeb[SUP] 1 2 [/SUP], Yuchong Li[SUP] 1 3 [/SUP], Haibo Zhang[SUP] 4 5 6 [/SUP]
Affiliations
- PMID: 34253247
- DOI: 10.1186/s13054-021-03662-x
Abstract
The major variant of concerns (VOCs) have shared mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike proteins, mostly on the S1 unit and resulted in higher transmissibility rate and affect viral virulence and clinical outcome. The spike protein mutations and other non-structural protein mutations in the VOCs may lead to escape approved vaccinations in certain extend. We will discuss these VOC mutations and discuss the need for combination therapeutic strategies targeting viral cycle and immune host responses.
Keywords: B.1.1.7; B.1.351; P.1. B.1617.1; Transmissibility; Viral virulence.