tetano
Editor, Senior Moderator
Crit Rev Clin Lab Sci
. 2023 Jul 13;1-30.
doi: 10.1080/10408363.2023.2232010. Online ahead of print. It's in the blood: a review of the hematological system in SARS-CoV-2-associated COVID-19
James V Harte[SUP] 1 2 [/SUP], Caroline Coleman-Vaughan[SUP] 3 [/SUP], Maeve P Crowley[SUP] 1 4 [/SUP], Vitaliy Mykytiv[SUP] 1 [/SUP]
Affiliations
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an unprecedented global healthcare crisis. While SARS-CoV-2-associated COVID-19 affects primarily the respiratory system, patients with COVID-19 frequently develop extrapulmonary manifestations. Notably, changes in the hematological system, including lymphocytopenia, neutrophilia and significant abnormalities of hemostatic markers, were observed early in the pandemic. Hematological manifestations have since been recognized as important parameters in the pathophysiology of SARS-CoV-2 and in the management of patients with COVID-19. In this narrative review, we summarize the state-of-the-art regarding the hematological and hemostatic abnormalities observed in patients with SARS-CoV-2-associated COVID-19, as well as the current understanding of the hematological system in the pathophysiology of acute and chronic SARS-CoV-2-associated COVID-19.
Keywords: Biomarkers; COVID-19; SARS-CoV-2; hematology; hemostasis.
. 2023 Jul 13;1-30.
doi: 10.1080/10408363.2023.2232010. Online ahead of print. It's in the blood: a review of the hematological system in SARS-CoV-2-associated COVID-19
James V Harte[SUP] 1 2 [/SUP], Caroline Coleman-Vaughan[SUP] 3 [/SUP], Maeve P Crowley[SUP] 1 4 [/SUP], Vitaliy Mykytiv[SUP] 1 [/SUP]
Affiliations
- PMID: 37439130
- DOI: 10.1080/10408363.2023.2232010
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an unprecedented global healthcare crisis. While SARS-CoV-2-associated COVID-19 affects primarily the respiratory system, patients with COVID-19 frequently develop extrapulmonary manifestations. Notably, changes in the hematological system, including lymphocytopenia, neutrophilia and significant abnormalities of hemostatic markers, were observed early in the pandemic. Hematological manifestations have since been recognized as important parameters in the pathophysiology of SARS-CoV-2 and in the management of patients with COVID-19. In this narrative review, we summarize the state-of-the-art regarding the hematological and hemostatic abnormalities observed in patients with SARS-CoV-2-associated COVID-19, as well as the current understanding of the hematological system in the pathophysiology of acute and chronic SARS-CoV-2-associated COVID-19.
Keywords: Biomarkers; COVID-19; SARS-CoV-2; hematology; hemostasis.