tetano
Editor, Senior Moderator
J Gen Virol. 2011 Jun 8. [Epub ahead of print]
Cross-protective immunity to influenza pH1N1 2009 viruses induced by seasonal A(H3N2) virus is mediated by virus-specific T cells.
Hillaire ML, van Trierum SE, Kreijtz JH, Bodewes R, Geelhoed-Mieras MM, Nieuwkoop NJ, Fouchier RA, Kuiken T, Osterhaus AD, Rimmelzwaan GF.
Source
Erasmus MC.
Abstract
Influenza A(H1N1) viruses of swine origin were introduced into the human population in 2009 and caused a pandemic. The disease burden in the elderly was relatively low, which was attributed to the presence of cross-reacting serum antibodies raised against seasonal influenza A(H1N1) viruses that circulated before 1957 in this age group. It has been described that also infection with heterosubtypic influenza viruses can induce some degree of protection against infection with a novel strain of influenza virus. Here we assess the extent of protective immunity to infection with the 2009 A(H1N1) pandemic influenza virus afforded by infection with a seasonal A(H3N2) virus in mice. Mice that experienced a primary A(H3N2) influenza virus infection displayed reduced weight loss after challenge infection and cleared the 2009 A(H1N1) virus infection more rapidly. To elucidate the correlates of protection of this heterosubtypic immunity to pandemic H1N1 virus infection, adoptive transfer experiments were carried out using selected post infection lymphocyte populations. Virus-specific CD8(+) T cells in concert with CD4(+) T cells were responsible for the observed protection. These findings may not only provide an explanation for epidemiological differences in the incidence of severe pandemic H1N1 infections, they also indicate that the induction of cross-reactive virus-specific CD8(+) and CD4(+) T cell responses may be a venue for the development of universal influenza vaccines.
PMID:
21653752
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21653752
Cross-protective immunity to influenza pH1N1 2009 viruses induced by seasonal A(H3N2) virus is mediated by virus-specific T cells.
Hillaire ML, van Trierum SE, Kreijtz JH, Bodewes R, Geelhoed-Mieras MM, Nieuwkoop NJ, Fouchier RA, Kuiken T, Osterhaus AD, Rimmelzwaan GF.
Source
Erasmus MC.
Abstract
Influenza A(H1N1) viruses of swine origin were introduced into the human population in 2009 and caused a pandemic. The disease burden in the elderly was relatively low, which was attributed to the presence of cross-reacting serum antibodies raised against seasonal influenza A(H1N1) viruses that circulated before 1957 in this age group. It has been described that also infection with heterosubtypic influenza viruses can induce some degree of protection against infection with a novel strain of influenza virus. Here we assess the extent of protective immunity to infection with the 2009 A(H1N1) pandemic influenza virus afforded by infection with a seasonal A(H3N2) virus in mice. Mice that experienced a primary A(H3N2) influenza virus infection displayed reduced weight loss after challenge infection and cleared the 2009 A(H1N1) virus infection more rapidly. To elucidate the correlates of protection of this heterosubtypic immunity to pandemic H1N1 virus infection, adoptive transfer experiments were carried out using selected post infection lymphocyte populations. Virus-specific CD8(+) T cells in concert with CD4(+) T cells were responsible for the observed protection. These findings may not only provide an explanation for epidemiological differences in the incidence of severe pandemic H1N1 infections, they also indicate that the induction of cross-reactive virus-specific CD8(+) and CD4(+) T cell responses may be a venue for the development of universal influenza vaccines.
PMID:
21653752
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21653752