tetano
Editor, Senior Moderator
BMJ Case Rep. 2012 Jan 10;2012. pii: bcr1120115224. doi: 10.1136/bcr.11.2011.5224.
Cryptococccal meningoencephalitis after H1N1 influenza.
Hosseinnezhad A, Rapose A.
Source
Department of Internal Medicine, Saint Vincent Hospital, Worcester, Massachusetts, USA.
Abstract
Cryptococcus neoformans is associated with a spectrum of diseases including meningoencephalitis, pneumonia and soft tissue infections. Incidence is higher in immunocompromised hosts like HIV-infected individuals and solid organ transplant recipients. The influenza virus is known to cause immunologic defects. Additionally, the 2009-pandemic H1N1 virus is associated with increased incidence of acute respiratory distress syndrome (ARDS) requiring treatment with systemic steroids. The authors present the first case of cryptococcal meningitis in a patient with flu A-associated ARDS (FLAARDS). In this patient, risk factors for invasive fungal disease included a combination of severe and prolonged H1N1-influenza virus infection, corticosteroid therapy and broad-spectrum antibiotics. While prolonged corticosteroid use is a known risk factor for development of invasive fungal disease, the authors postulate that by causing immunologic defects and FLAARDS, the 2009-pandemic H1N1 virus may represent an additional independent risk for the development of C neoformans meningitis in a previously healthy individual.
PMID:
22665712
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/22665712
Cryptococccal meningoencephalitis after H1N1 influenza.
Hosseinnezhad A, Rapose A.
Source
Department of Internal Medicine, Saint Vincent Hospital, Worcester, Massachusetts, USA.
Abstract
Cryptococcus neoformans is associated with a spectrum of diseases including meningoencephalitis, pneumonia and soft tissue infections. Incidence is higher in immunocompromised hosts like HIV-infected individuals and solid organ transplant recipients. The influenza virus is known to cause immunologic defects. Additionally, the 2009-pandemic H1N1 virus is associated with increased incidence of acute respiratory distress syndrome (ARDS) requiring treatment with systemic steroids. The authors present the first case of cryptococcal meningitis in a patient with flu A-associated ARDS (FLAARDS). In this patient, risk factors for invasive fungal disease included a combination of severe and prolonged H1N1-influenza virus infection, corticosteroid therapy and broad-spectrum antibiotics. While prolonged corticosteroid use is a known risk factor for development of invasive fungal disease, the authors postulate that by causing immunologic defects and FLAARDS, the 2009-pandemic H1N1 virus may represent an additional independent risk for the development of C neoformans meningitis in a previously healthy individual.
PMID:
22665712
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/22665712