tetano
Editor, Senior Moderator
Cureus
. 2024 Jan 26;16(1):e52981.
doi: 10.7759/cureus.52981. eCollection 2024 Jan. A Case of Combination of IgA Nephropathy and Interstitial Nephritis After COVID-19 Vaccination
Yuki Yoshida[SUP] 1 [/SUP], Kenta Torigoe[SUP] 1 [/SUP], Ryosuke Sakamoto[SUP] 1 [/SUP], Shinichi Abe[SUP] 1 [/SUP], Kumiko Muta[SUP] 1 [/SUP], Hiroshi Mukae[SUP] 2 [/SUP], Tomoya Nishino[SUP] 1 [/SUP]
Affiliations
A 66-year-old male presented with renal dysfunction. At the time of presentation, his serum creatinine (sCr) was 2.55 mg/dL, estimated glomerular filtration rate (eGFR) was 20.93 ml/min/1.73 m[SUP]2[/SUP], urinary red blood cell (RBC) was 30-49/high power field, and urine protein-creatinine ratio was 0.43 g/gCr. The patient had no urinalysis abnormalities or renal dysfunction within the year prior to presentation but had gross hematuria after the third and fourth coronavirus disease 2019 (COVID-19) vaccinations. Therefore, immunoglobulin A nephropathy (IgAN) was suspected and a percutaneous renal biopsy was performed. Renal pathology confirmed IgAN and interstitial nephritis and glucocorticoid therapy was initiated. Glucocorticoids improved renal function, and microscopic hematuria resolved. Although previous reports have shown that the COVID-19 vaccine induces various renal diseases, complications associated with these two renal diseases are rare. In this case, while IgAN was suspected based on episodes of gross hematuria after vaccination, renal biopsy confirmed it and also revealed interstitial nephritis.
Keywords: covid-19 vaccine; glomerular nephritis; iga nephropathy (igan); severe acute respiratory syndrome coronavirus 2; tubulointerstitial nephritis.
. 2024 Jan 26;16(1):e52981.
doi: 10.7759/cureus.52981. eCollection 2024 Jan. A Case of Combination of IgA Nephropathy and Interstitial Nephritis After COVID-19 Vaccination
Yuki Yoshida[SUP] 1 [/SUP], Kenta Torigoe[SUP] 1 [/SUP], Ryosuke Sakamoto[SUP] 1 [/SUP], Shinichi Abe[SUP] 1 [/SUP], Kumiko Muta[SUP] 1 [/SUP], Hiroshi Mukae[SUP] 2 [/SUP], Tomoya Nishino[SUP] 1 [/SUP]
Affiliations
- PMID: 38406008
- PMCID: PMC10894454
- DOI: 10.7759/cureus.52981
A 66-year-old male presented with renal dysfunction. At the time of presentation, his serum creatinine (sCr) was 2.55 mg/dL, estimated glomerular filtration rate (eGFR) was 20.93 ml/min/1.73 m[SUP]2[/SUP], urinary red blood cell (RBC) was 30-49/high power field, and urine protein-creatinine ratio was 0.43 g/gCr. The patient had no urinalysis abnormalities or renal dysfunction within the year prior to presentation but had gross hematuria after the third and fourth coronavirus disease 2019 (COVID-19) vaccinations. Therefore, immunoglobulin A nephropathy (IgAN) was suspected and a percutaneous renal biopsy was performed. Renal pathology confirmed IgAN and interstitial nephritis and glucocorticoid therapy was initiated. Glucocorticoids improved renal function, and microscopic hematuria resolved. Although previous reports have shown that the COVID-19 vaccine induces various renal diseases, complications associated with these two renal diseases are rare. In this case, while IgAN was suspected based on episodes of gross hematuria after vaccination, renal biopsy confirmed it and also revealed interstitial nephritis.
Keywords: covid-19 vaccine; glomerular nephritis; iga nephropathy (igan); severe acute respiratory syndrome coronavirus 2; tubulointerstitial nephritis.