tetano
Editor, Senior Moderator
Cureus
. 2021 Dec 14;13(12):e20410.
doi: 10.7759/cureus.20410. eCollection 2021 Dec.
Acute Pancreatitis Due to COVID-19 Active Infection
Frank H Annie[SUP] 1 [/SUP], Julton Chumbe[SUP] 2 [/SUP], Lauren Searls[SUP] 2 [/SUP], Jessica Amos[SUP] 2 [/SUP], James Campbell[SUP] 2 [/SUP], Suzanne Kemper[SUP] 3 [/SUP], Sarah Embrey[SUP] 4 [/SUP], Muhammad Bashir[SUP] 5 [/SUP]
Affiliations
Abstract
Background This study investigates the relationship between coronavirus disease 2019 (COVID-19) infection and acute pancreatitis. We present large registry data assessing the association between acute pancreatitis and mortality in patients with COVID-19 post-infection. Methods The researchers identified adult patients aged 18-90 years with COVID-19 infections in the TriNetX (COVID-19 research network) database between January 20, 2020, and June 1, 2021. The researchers identified n=1,039,688 cases divided into two cohorts: those with post-acute pancreatitis (n= 1,173) and those without post-acute pancreatitis (n=1,038,515) post COVID-19 infection having follow-up within a two-week period. The researchers then conducted a 1:1 propensity score match to account for differences in the cohorts and created two well-matched cohorts (n=1,173/1,173). Results Patients that developed acute pancreatitis had higher mortality (12.4% vs 3.7%, p<0.001), stroke (3.6% vs 1.7%, p=0.005), higher inpatient admissions (28.2% vs 10.6%, p<0.001), and higher rates of ICU admission (9.5% vs 3.2%, p<0.001). Conclusion In a large multinational federated database, we observed higher mortality, stroke, higher inpatient admissions, and higher rates of ICU admissions among patients with COVID-19 with pancreatitis.
Keywords: acute pancreatitis due to covid-19; covid-19; icu admission; inpatient admissions; mortality.
. 2021 Dec 14;13(12):e20410.
doi: 10.7759/cureus.20410. eCollection 2021 Dec.
Acute Pancreatitis Due to COVID-19 Active Infection
Frank H Annie[SUP] 1 [/SUP], Julton Chumbe[SUP] 2 [/SUP], Lauren Searls[SUP] 2 [/SUP], Jessica Amos[SUP] 2 [/SUP], James Campbell[SUP] 2 [/SUP], Suzanne Kemper[SUP] 3 [/SUP], Sarah Embrey[SUP] 4 [/SUP], Muhammad Bashir[SUP] 5 [/SUP]
Affiliations
- PMID: 35047252
- PMCID: PMC8757391
- DOI: 10.7759/cureus.20410
Abstract
Background This study investigates the relationship between coronavirus disease 2019 (COVID-19) infection and acute pancreatitis. We present large registry data assessing the association between acute pancreatitis and mortality in patients with COVID-19 post-infection. Methods The researchers identified adult patients aged 18-90 years with COVID-19 infections in the TriNetX (COVID-19 research network) database between January 20, 2020, and June 1, 2021. The researchers identified n=1,039,688 cases divided into two cohorts: those with post-acute pancreatitis (n= 1,173) and those without post-acute pancreatitis (n=1,038,515) post COVID-19 infection having follow-up within a two-week period. The researchers then conducted a 1:1 propensity score match to account for differences in the cohorts and created two well-matched cohorts (n=1,173/1,173). Results Patients that developed acute pancreatitis had higher mortality (12.4% vs 3.7%, p<0.001), stroke (3.6% vs 1.7%, p=0.005), higher inpatient admissions (28.2% vs 10.6%, p<0.001), and higher rates of ICU admission (9.5% vs 3.2%, p<0.001). Conclusion In a large multinational federated database, we observed higher mortality, stroke, higher inpatient admissions, and higher rates of ICU admissions among patients with COVID-19 with pancreatitis.
Keywords: acute pancreatitis due to covid-19; covid-19; icu admission; inpatient admissions; mortality.