tetano
Editor, Senior Moderator
Cureus
. 2023 Feb 27;15(2):e35527.
doi: 10.7759/cureus.35527. eCollection 2023 Feb.
Adult-Onset IgA Vasculitis Associated With Pulmonary-Renal Syndrome Following COVID-19 Infection: A Case Report and Literature Review
Hassan Alwafi[SUP] 1 [/SUP], Deema Ashoor[SUP] 2 [/SUP], Mohammad Dairi[SUP] 3 [/SUP], Ghadeer Mokhtar[SUP] 4 [/SUP], Khaled Dairi[SUP] 5 [/SUP]
Affiliations
Abstract
Immunoglobulin A (IgA) vasculitis, also known as Henoch-Schönlein purpura (HSP), is an immune complex-mediated inflammation of small blood vessels that leads to tissue destruction with or without organ damage. We described a case of a 41-year-old otherwise healthy female who presented with an ascending rash distributed on both lower extremities and arthralgia. Blood testing revealed high blood urea nitrogen (BUN), creatinine, and inflammatory markers, as well as a negative autoimmune panel. Urinalysis revealed proteinuria and hematuria. A kidney biopsy was performed, which revealed abnormalities. She was started on intravenous (IV) methylprednisolone pulse therapy. Suddenly, she complained of epistaxis and became desaturated. Computed tomography revealed bilateral pleural effusion, and she was transferred to the ICU. Bronchoalveolar lavage was performed and was consistent with an increasing bloodier return. Plasma exchange was performed. The rash and clinical symptoms improved dramatically. This study reports a case of IgA vasculitis based on The European Alliance of Associations for Rheumatology/Pediatric Rheumatology International Trials Organization/Pediatric Rheumatology European Society (EULAR/PRINTO/PRES) criteria associated with pulmonary-renal syndrome following a case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Keywords: adult iga vasculitis; covid-19; henoch-schönlein purpura (iga vasculitis); pulmonary-renal syndrome; sars-cov-2.
. 2023 Feb 27;15(2):e35527.
doi: 10.7759/cureus.35527. eCollection 2023 Feb.
Adult-Onset IgA Vasculitis Associated With Pulmonary-Renal Syndrome Following COVID-19 Infection: A Case Report and Literature Review
Hassan Alwafi[SUP] 1 [/SUP], Deema Ashoor[SUP] 2 [/SUP], Mohammad Dairi[SUP] 3 [/SUP], Ghadeer Mokhtar[SUP] 4 [/SUP], Khaled Dairi[SUP] 5 [/SUP]
Affiliations
- PMID: 37007348
- PMCID: PMC10054844
- DOI: 10.7759/cureus.35527
Abstract
Immunoglobulin A (IgA) vasculitis, also known as Henoch-Schönlein purpura (HSP), is an immune complex-mediated inflammation of small blood vessels that leads to tissue destruction with or without organ damage. We described a case of a 41-year-old otherwise healthy female who presented with an ascending rash distributed on both lower extremities and arthralgia. Blood testing revealed high blood urea nitrogen (BUN), creatinine, and inflammatory markers, as well as a negative autoimmune panel. Urinalysis revealed proteinuria and hematuria. A kidney biopsy was performed, which revealed abnormalities. She was started on intravenous (IV) methylprednisolone pulse therapy. Suddenly, she complained of epistaxis and became desaturated. Computed tomography revealed bilateral pleural effusion, and she was transferred to the ICU. Bronchoalveolar lavage was performed and was consistent with an increasing bloodier return. Plasma exchange was performed. The rash and clinical symptoms improved dramatically. This study reports a case of IgA vasculitis based on The European Alliance of Associations for Rheumatology/Pediatric Rheumatology International Trials Organization/Pediatric Rheumatology European Society (EULAR/PRINTO/PRES) criteria associated with pulmonary-renal syndrome following a case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Keywords: adult iga vasculitis; covid-19; henoch-schönlein purpura (iga vasculitis); pulmonary-renal syndrome; sars-cov-2.