tetano
Editor, Senior Moderator
Cureus
. 2022 May 24;14(5):e25286.
doi: 10.7759/cureus.25286. eCollection 2022 May.
Clinical Characteristics, Comorbidities, and Outcome of Critically Sick Patients With COVID-19 Pneumonia Admitted in the Intensive Care Unit of a Tertiary Care Hospital in Lahore, Pakistan: A Retrospective Cohort Study
Aijaz Zeeshan Khan Chachar[SUP] 1 [/SUP], Mohsin Asif[SUP] 1 [/SUP], Khushbakht Tanveer[SUP] 2 [/SUP], Muhammad K Rauf[SUP] 1 [/SUP], Javeid Iqbal[SUP] 1 [/SUP], Kinza Khan[SUP] 3 [/SUP], Zohaib Khan[SUP] 4 [/SUP], Bilal Bin Younis[SUP] 1 [/SUP], Khurshid Khan[SUP] 5 [/SUP]
Affiliations
Abstract
Background Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a multisystem disease that primarily involves the respiratory tract. The first case of COVID-19 was identified in late 2019 in the province of Wuhan, China, which was followed by the rapid spread of the disease globally, becoming a present-day pandemic. Objectives The aim of this study is to describe the clinical characteristics, comorbidities, and outcomes of critically sick patients with COVID-19 pneumonia admitted to the intensive care unit (ICU) of Fatima Memorial Hospital, Lahore, from March 2021 to August 2021. A total of 133 patients were chosen for this retrospective cohort study. Results There was a total of 133 patients, out of which 65 (48.9%) were male and 68 (51.1%) were female. Of these 133 patients, 70 (52.6%) were discharged home after recovery and 63 (47.4%) died; 96 (72.2%) patients had diabetes mellitus and of these, 53 (55.2%) patients died and 43 (44.8%) were discharged, 94 (70.7%) patients had hypertension, out of which 53 (56.4%) died and 41 (43.6%) were discharged home, 40 (30.1%) patients had ischemic heart disease (IHD), out of which 28 (70%) died and 12 (30%) were discharged. A total of 48 (36.1%) patients needed invasive positive pressure ventilation (IPPV) and 78 (58.6%) patients required noninvasive positive pressure ventilation (NIPPV). Conclusion Patients with one or more underlying co-morbidities had poor clinical outcomes compared to those with no co-morbidities, with the most vulnerable group being patients with Ischemic heart disease, chronic kidney disease, hypertension, and diabetes mellitus in descending order.
Keywords: comorbidities; covid-19; covid-19 and diabetes; covid-19 pneumonia; critically sick; hypertension and covid-19; intensive care; ischemic heart disease.
. 2022 May 24;14(5):e25286.
doi: 10.7759/cureus.25286. eCollection 2022 May.
Clinical Characteristics, Comorbidities, and Outcome of Critically Sick Patients With COVID-19 Pneumonia Admitted in the Intensive Care Unit of a Tertiary Care Hospital in Lahore, Pakistan: A Retrospective Cohort Study
Aijaz Zeeshan Khan Chachar[SUP] 1 [/SUP], Mohsin Asif[SUP] 1 [/SUP], Khushbakht Tanveer[SUP] 2 [/SUP], Muhammad K Rauf[SUP] 1 [/SUP], Javeid Iqbal[SUP] 1 [/SUP], Kinza Khan[SUP] 3 [/SUP], Zohaib Khan[SUP] 4 [/SUP], Bilal Bin Younis[SUP] 1 [/SUP], Khurshid Khan[SUP] 5 [/SUP]
Affiliations
- PMID: 35755515
- PMCID: PMC9224701
- DOI: 10.7759/cureus.25286
Abstract
Background Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a multisystem disease that primarily involves the respiratory tract. The first case of COVID-19 was identified in late 2019 in the province of Wuhan, China, which was followed by the rapid spread of the disease globally, becoming a present-day pandemic. Objectives The aim of this study is to describe the clinical characteristics, comorbidities, and outcomes of critically sick patients with COVID-19 pneumonia admitted to the intensive care unit (ICU) of Fatima Memorial Hospital, Lahore, from March 2021 to August 2021. A total of 133 patients were chosen for this retrospective cohort study. Results There was a total of 133 patients, out of which 65 (48.9%) were male and 68 (51.1%) were female. Of these 133 patients, 70 (52.6%) were discharged home after recovery and 63 (47.4%) died; 96 (72.2%) patients had diabetes mellitus and of these, 53 (55.2%) patients died and 43 (44.8%) were discharged, 94 (70.7%) patients had hypertension, out of which 53 (56.4%) died and 41 (43.6%) were discharged home, 40 (30.1%) patients had ischemic heart disease (IHD), out of which 28 (70%) died and 12 (30%) were discharged. A total of 48 (36.1%) patients needed invasive positive pressure ventilation (IPPV) and 78 (58.6%) patients required noninvasive positive pressure ventilation (NIPPV). Conclusion Patients with one or more underlying co-morbidities had poor clinical outcomes compared to those with no co-morbidities, with the most vulnerable group being patients with Ischemic heart disease, chronic kidney disease, hypertension, and diabetes mellitus in descending order.
Keywords: comorbidities; covid-19; covid-19 and diabetes; covid-19 pneumonia; critically sick; hypertension and covid-19; intensive care; ischemic heart disease.