tetano
Editor, Senior Moderator
Cureus
. 2023 Jun 23;15(6):e40860.
doi: 10.7759/cureus.40860. eCollection 2023 Jun. Trend of SARS-Cov-2-Specific IgG Antibody Titers Among COVID-19 Pneumonia Patients: A Nine-Month Follow-Up
Manzoor Ahmad[SUP] 1 [/SUP], Mohammad Muttahir Uddin[SUP] 2 [/SUP], Abdul Ahad Wani[SUP] 1 [/SUP], Ishrat Majeed[SUP] 2 [/SUP], Ruquaya Aziz[SUP] 3 [/SUP], Mubarak Naqash[SUP] 4 [/SUP]
Affiliations
Introduction Understanding the dynamics of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) spike antibody titers after natural infection is important for understanding immunological memory. This longitudinal study was conducted to assess the trend in serum SARS-CoV-2 IgG spike antibody titers in a cohort of recovered cases up to nine months after SARS infection. Materials and methods We examined the neutralizing antibody response (IgG spike) in serum samples from a cohort of 86 SARS-CoV-2 quantitative polymerase chain reaction (qPCR)-confirmed infection, comprising cases having minor COVID-19 pneumonia and severity, which was determined by CT severity scores. Patients were enrolled in August/September 2020 and serum samples have been processed at one, three, six, and nine months. CT severity scores were rated between 1-25 and antibody titers≥ 1.4 were considered positive. Results The mean anti-SARS-CoV-2-specific IgG antibody titers at one month, three months, six months, and nine months were 22.02 ± 18.36, 14.62 ± 12.61, 8.93 ± 8.10, and 3.86 ± 5.70, respectively. The difference was statistically significant. The seropositivity rates (titer ≥1.4 IU) were 93.02%, 82.56%, 76.74%, and 58.14% at one, three, six, and nine months after infection, respectively. Cases with severe CT severity scores showed significantly higher mean antibody levels at all follow-up visits.
Keywords: coronavirus disease 19 pneumonia; immunological memory; prospective study; reverse-transcription polymerase chain reaction (rt-pcr) test; seropositivity rates; severe acute respiratory syndrome coronavirus 2 specific igg antibody titres; supplemental oxygen.
. 2023 Jun 23;15(6):e40860.
doi: 10.7759/cureus.40860. eCollection 2023 Jun. Trend of SARS-Cov-2-Specific IgG Antibody Titers Among COVID-19 Pneumonia Patients: A Nine-Month Follow-Up
Manzoor Ahmad[SUP] 1 [/SUP], Mohammad Muttahir Uddin[SUP] 2 [/SUP], Abdul Ahad Wani[SUP] 1 [/SUP], Ishrat Majeed[SUP] 2 [/SUP], Ruquaya Aziz[SUP] 3 [/SUP], Mubarak Naqash[SUP] 4 [/SUP]
Affiliations
- PMID: 37489184
- PMCID: PMC10363370
- DOI: 10.7759/cureus.40860
Introduction Understanding the dynamics of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) spike antibody titers after natural infection is important for understanding immunological memory. This longitudinal study was conducted to assess the trend in serum SARS-CoV-2 IgG spike antibody titers in a cohort of recovered cases up to nine months after SARS infection. Materials and methods We examined the neutralizing antibody response (IgG spike) in serum samples from a cohort of 86 SARS-CoV-2 quantitative polymerase chain reaction (qPCR)-confirmed infection, comprising cases having minor COVID-19 pneumonia and severity, which was determined by CT severity scores. Patients were enrolled in August/September 2020 and serum samples have been processed at one, three, six, and nine months. CT severity scores were rated between 1-25 and antibody titers≥ 1.4 were considered positive. Results The mean anti-SARS-CoV-2-specific IgG antibody titers at one month, three months, six months, and nine months were 22.02 ± 18.36, 14.62 ± 12.61, 8.93 ± 8.10, and 3.86 ± 5.70, respectively. The difference was statistically significant. The seropositivity rates (titer ≥1.4 IU) were 93.02%, 82.56%, 76.74%, and 58.14% at one, three, six, and nine months after infection, respectively. Cases with severe CT severity scores showed significantly higher mean antibody levels at all follow-up visits.
Keywords: coronavirus disease 19 pneumonia; immunological memory; prospective study; reverse-transcription polymerase chain reaction (rt-pcr) test; seropositivity rates; severe acute respiratory syndrome coronavirus 2 specific igg antibody titres; supplemental oxygen.