tetano
Editor, Senior Moderator
Curr Drug Saf
. 2022 Mar 4.
doi: 10.2174/1574886317666220304122420. Online ahead of print.
Complications and Efficacy of Sinopharm Vaccine among Liver and Kidney Transplantation
Rozita Khodashahi[SUP] 1 [/SUP], Mohsen Aliakbarian[SUP] 2 [/SUP], Mahin Ghorban Sabbagh[SUP] 3 [/SUP], Kambiz Akhavan Rezayat[SUP] 4 [/SUP], Mandana Khodashahi[SUP] 5 [/SUP], Ebrahim Khaleghi[SUP] 6 [/SUP], Maliheh Dadgar Moghaddam[SUP] 7 [/SUP], Baran Razmkhah[SUP] 5 [/SUP], Mahdi Nik Nazar[SUP] 5 [/SUP], Nadia Sheikhi[SUP] 5 [/SUP]
Affiliations
Abstract
Background: There are various vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, vaccination may lead to some complications.
Objective: This study aimed to investigate the complications of transplant recipients who received Sinopharm COVID-19 vaccine.
Methods: This was a retrospective cross-sectional study conducted among 667 transplant recipients (211 liver transplant recipients and 456 kidney transplant recipients), who received the Sinopharm COVID-19 vaccine during March to August 2021 and had medical records in Montaserieh Hospital, affiliated to Mashhad University of Medical Sciences, Mashhad, Iran. The demographic and clinical information as well as patient's symptoms after each dose of the vaccine were recorded.
Results: Only 16.8% and 13.7% of the patients experienced some symptoms following the first and second doses of Sinopharm vaccine, respectively. No significant difference was observed between patients younger than 50 years and those aged 50 years and over in terms of complication rate of Sinopharm vaccine (P>0.005). Vaccine failure was reported in 10% of the cases; however, mortality rate due to infection with the Delta variant of COVID-19 in this population was reported to be 0.7%.
Conclusion: Based on the obtained results, adverse reactions of the Sinopharm COVID-19 vaccine are generally mild, predictable, and non-life-threatening both in the first and second doses. Vaccine failure was reported in 10% of the cases; however, mortality due to infection with the Delta variant of COVID-19 was reported in less than 1% of the cases.
Keywords: COVID-19; Sinopharm vaccine.; infection; side effects; transplant; vaccination.
. 2022 Mar 4.
doi: 10.2174/1574886317666220304122420. Online ahead of print.
Complications and Efficacy of Sinopharm Vaccine among Liver and Kidney Transplantation
Rozita Khodashahi[SUP] 1 [/SUP], Mohsen Aliakbarian[SUP] 2 [/SUP], Mahin Ghorban Sabbagh[SUP] 3 [/SUP], Kambiz Akhavan Rezayat[SUP] 4 [/SUP], Mandana Khodashahi[SUP] 5 [/SUP], Ebrahim Khaleghi[SUP] 6 [/SUP], Maliheh Dadgar Moghaddam[SUP] 7 [/SUP], Baran Razmkhah[SUP] 5 [/SUP], Mahdi Nik Nazar[SUP] 5 [/SUP], Nadia Sheikhi[SUP] 5 [/SUP]
Affiliations
- PMID: 35249504
- DOI: 10.2174/1574886317666220304122420
Abstract
Background: There are various vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, vaccination may lead to some complications.
Objective: This study aimed to investigate the complications of transplant recipients who received Sinopharm COVID-19 vaccine.
Methods: This was a retrospective cross-sectional study conducted among 667 transplant recipients (211 liver transplant recipients and 456 kidney transplant recipients), who received the Sinopharm COVID-19 vaccine during March to August 2021 and had medical records in Montaserieh Hospital, affiliated to Mashhad University of Medical Sciences, Mashhad, Iran. The demographic and clinical information as well as patient's symptoms after each dose of the vaccine were recorded.
Results: Only 16.8% and 13.7% of the patients experienced some symptoms following the first and second doses of Sinopharm vaccine, respectively. No significant difference was observed between patients younger than 50 years and those aged 50 years and over in terms of complication rate of Sinopharm vaccine (P>0.005). Vaccine failure was reported in 10% of the cases; however, mortality rate due to infection with the Delta variant of COVID-19 in this population was reported to be 0.7%.
Conclusion: Based on the obtained results, adverse reactions of the Sinopharm COVID-19 vaccine are generally mild, predictable, and non-life-threatening both in the first and second doses. Vaccine failure was reported in 10% of the cases; however, mortality due to infection with the Delta variant of COVID-19 was reported in less than 1% of the cases.
Keywords: COVID-19; Sinopharm vaccine.; infection; side effects; transplant; vaccination.