tetano
Editor, Senior Moderator
Curr Drug Targets
. 2020 Dec 28.
doi: 10.2174/1389450121666201228122845. Online ahead of print.
A Review on Screening Models for Potential Therapeutic Candidates and Targets Against SARS-CoV-2
Mohana Das[SUP] 1 [/SUP], Manish Kumar[SUP] 1 [/SUP], Abhishek Jha[SUP] 1 [/SUP], Madhukiran D R[SUP] 1 [/SUP], Kanchan Bharti[SUP] 1 [/SUP], Shomedeep Mondal[SUP] 1 [/SUP], Brahmeshwar Mishra[SUP] 1 [/SUP]
Affiliations
Abstract
Coronaviruses are a group of known RNA virus which primarily infects the respiratory tract, and also neurological, enteric, and hepatic systems. Endemic outbreaks of Middle East Coronavirus Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) have been observed in recent decades. A new strain named the SARS CoV-2(COVID-19) virus has now spread across the globe. SARS-CoV-2 is highly communicable and has culminated in a massive pandemic of COVID-19. Currently, no successful treatment is available. Therefore, an urgent need is there for new screening models that can aid in identifying the drugs with potential activity against COVID-19. The current review aims to discuss various in-silico, in-vitro and in-vivo screening methods, that can potentially be used to expedite the discovery of new active therapeutic candidates and vaccines, drug targets, and repurposing the commercially available drugs against COVID-19 for the effective management of the infection and thereby controlling this pandemic. Further, the current status of drugs and vaccines under clinical investigation has been summarized.
Keywords: COVID-19; Corona Virus; SARS-CoV.1. Introduction; Screening Models.
. 2020 Dec 28.
doi: 10.2174/1389450121666201228122845. Online ahead of print.
A Review on Screening Models for Potential Therapeutic Candidates and Targets Against SARS-CoV-2
Mohana Das[SUP] 1 [/SUP], Manish Kumar[SUP] 1 [/SUP], Abhishek Jha[SUP] 1 [/SUP], Madhukiran D R[SUP] 1 [/SUP], Kanchan Bharti[SUP] 1 [/SUP], Shomedeep Mondal[SUP] 1 [/SUP], Brahmeshwar Mishra[SUP] 1 [/SUP]
Affiliations
- PMID: 33371846
- DOI: 10.2174/1389450121666201228122845
Abstract
Coronaviruses are a group of known RNA virus which primarily infects the respiratory tract, and also neurological, enteric, and hepatic systems. Endemic outbreaks of Middle East Coronavirus Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) have been observed in recent decades. A new strain named the SARS CoV-2(COVID-19) virus has now spread across the globe. SARS-CoV-2 is highly communicable and has culminated in a massive pandemic of COVID-19. Currently, no successful treatment is available. Therefore, an urgent need is there for new screening models that can aid in identifying the drugs with potential activity against COVID-19. The current review aims to discuss various in-silico, in-vitro and in-vivo screening methods, that can potentially be used to expedite the discovery of new active therapeutic candidates and vaccines, drug targets, and repurposing the commercially available drugs against COVID-19 for the effective management of the infection and thereby controlling this pandemic. Further, the current status of drugs and vaccines under clinical investigation has been summarized.
Keywords: COVID-19; Corona Virus; SARS-CoV.1. Introduction; Screening Models.