tetano
Editor, Senior Moderator
Curr Med Imaging
. 2021 Sep 17.
doi: 10.2174/1573405617666210917125045. Online ahead of print.
Imaging Findings for Identifying and Evaluating Complications after Lung Transplantation in Patients with Advanced COVID-19: Two Case Reports
Junhan Pan[SUP] 1 [/SUP], Manhua Zhu[SUP] 2 [/SUP], Weili Han[SUP] 2 [/SUP], Feng Chen[SUP] 1 [/SUP]
Affiliations
Abstract
Lung transplantation might be a viable alternative for patients with irreversible lung injury secondary to coronavirus disease 2019 (COVID-19). Here, we describe two patients with end-stage COVID-19 that received lung transplantations, the clinical-radiologic manifestations of post-operative complications, and the imaging features of allograft rejection. <p> Case presentation: Case 1, a 66-year-old woman presented severe hypoxia after lung transplantation. Chest imaging revealed diffuse homogeneous infiltration in the donor lung. Dramatic resolution of the imaging abnormalities after intravenous administration of methylprednisolone favored a diagnosis of hyperacute rejection. The second is a 70-year-old man, who was infected with bacterial postoperatively. During the empiric antibiotic therapy, chest CT showed newly developed ground glass opacities with septal thickening, suggesting a diagnosis of acute rejection. High-dose corticosteroids therapy was initiated, and the patient recovered gradually. <p> Conclusion: This is the first report describing post-operative complications of lung transplantation in patients with advanced COVID-19. We presumed that imaging procedures could be a useful tool in early detecting lung transplant complications and selecting specific interventions for patients with COVID-19.
Keywords: COVID-19; allograft rejection; case report; computed tomography; infection; lung transplantation.
. 2021 Sep 17.
doi: 10.2174/1573405617666210917125045. Online ahead of print.
Imaging Findings for Identifying and Evaluating Complications after Lung Transplantation in Patients with Advanced COVID-19: Two Case Reports
Junhan Pan[SUP] 1 [/SUP], Manhua Zhu[SUP] 2 [/SUP], Weili Han[SUP] 2 [/SUP], Feng Chen[SUP] 1 [/SUP]
Affiliations
- PMID: 34533448
- DOI: 10.2174/1573405617666210917125045
Abstract
Lung transplantation might be a viable alternative for patients with irreversible lung injury secondary to coronavirus disease 2019 (COVID-19). Here, we describe two patients with end-stage COVID-19 that received lung transplantations, the clinical-radiologic manifestations of post-operative complications, and the imaging features of allograft rejection. <p> Case presentation: Case 1, a 66-year-old woman presented severe hypoxia after lung transplantation. Chest imaging revealed diffuse homogeneous infiltration in the donor lung. Dramatic resolution of the imaging abnormalities after intravenous administration of methylprednisolone favored a diagnosis of hyperacute rejection. The second is a 70-year-old man, who was infected with bacterial postoperatively. During the empiric antibiotic therapy, chest CT showed newly developed ground glass opacities with septal thickening, suggesting a diagnosis of acute rejection. High-dose corticosteroids therapy was initiated, and the patient recovered gradually. <p> Conclusion: This is the first report describing post-operative complications of lung transplantation in patients with advanced COVID-19. We presumed that imaging procedures could be a useful tool in early detecting lung transplant complications and selecting specific interventions for patients with COVID-19.
Keywords: COVID-19; allograft rejection; case report; computed tomography; infection; lung transplantation.