tetano
Editor, Senior Moderator
Curr Med Res Opin
. 2022 Apr 11;1-10.
doi: 10.1080/03007995.2022.2065140. Online ahead of print.
Do compromised mitochondria aggravate severity and fatality by SARS-CoV-2?
Nilesh Kumar Sharma[SUP] 1 [/SUP], Sachin C Sarode[SUP] 2 [/SUP]
Affiliations
Abstract
At global level, pandemic coronavirus disease 2019 (COVID-19) is known to be caused by an etiologic agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Numerous evidence and propositions have emerged on the molecular and cellular attributes that cause COVID-19. Notwithstanding, still several key questions with reference to molecular aspects of severity of infection by SARS-CoV-2 need to be answered. In the same line, the role of healthy mitochondria to maintain intracellular temperature and their association with the severity of SARS-CoV-2 is completely missing. In this direction, preclinical and clinical data on the comorbidities in case of mitochondrial defective disease and COVID-19 are not available. The authors propose that patients harboring primary mitochondrial Disease and secondary mitochondrial dysfunction will display higher severity and death rate compared to healthy mitochondria harboring patients.
Keywords: ACE-2; COVID-19; Intracellular temperature; Mitochondria; SPIKE protein.
. 2022 Apr 11;1-10.
doi: 10.1080/03007995.2022.2065140. Online ahead of print.
Do compromised mitochondria aggravate severity and fatality by SARS-CoV-2?
Nilesh Kumar Sharma[SUP] 1 [/SUP], Sachin C Sarode[SUP] 2 [/SUP]
Affiliations
- PMID: 35403526
- DOI: 10.1080/03007995.2022.2065140
Abstract
At global level, pandemic coronavirus disease 2019 (COVID-19) is known to be caused by an etiologic agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Numerous evidence and propositions have emerged on the molecular and cellular attributes that cause COVID-19. Notwithstanding, still several key questions with reference to molecular aspects of severity of infection by SARS-CoV-2 need to be answered. In the same line, the role of healthy mitochondria to maintain intracellular temperature and their association with the severity of SARS-CoV-2 is completely missing. In this direction, preclinical and clinical data on the comorbidities in case of mitochondrial defective disease and COVID-19 are not available. The authors propose that patients harboring primary mitochondrial Disease and secondary mitochondrial dysfunction will display higher severity and death rate compared to healthy mitochondria harboring patients.
Keywords: ACE-2; COVID-19; Intracellular temperature; Mitochondria; SPIKE protein.