tetano
Editor, Senior Moderator
Curr Microbiol
. 2024 Feb 14;81(4):95.
doi: 10.1007/s00284-023-03603-7. Rapid Decline of SARS-CoV-2 Viral Load in Single vs. Double-Dose (Short-Interval <6 Weeks) ChAdOx nCoV-19 Vaccinated Health-Care Workers
Arnab Ghosh[SUP] #[/SUP][SUP] 1 [/SUP], Poonam Kanta[SUP] #[/SUP][SUP] 1 [/SUP], Manisha Ramola[SUP] 1 [/SUP], Ritin Mohindra[SUP] 2 [/SUP], Kapil Goyal[SUP] 1 [/SUP], Roop Kishore[SUP] 2 [/SUP], Vikas Suri[SUP] 2 [/SUP], P V M Lakshmi[SUP] 3 [/SUP], Chanderkanta Chauhan[SUP] 3 [/SUP], Manisha Sharma[SUP] 3 [/SUP], Partha Rakshit[SUP] 4 [/SUP], Kalaiarasan Ponnusamy[SUP] 4 [/SUP], Tanzin Dikid[SUP] 4 [/SUP], Mini P Singh[SUP] 5 [/SUP]
Affiliations
The present work was carried out during the emergence of Delta Variant of Concern (VoC) and aimed to study the change in SARS CoV-2 viral load in Covishield vaccinated asymptomatic/mildly symptomatic health-care workers (HCWs) to find out the optimum isolation period. The SARS CoV-2 viral load was carried out in sequential samples of 55 eligible HCWs which included unvaccinated (UnV; n = 11), single-dose vaccinated (SDV, n = 20) and double-dose vaccinated [DDV, n = 24; short-interval (<6 weeks)] subjects. The mean load of envelope (E) gene on day 5 in SDV [0.42 × 10[SUP]5[/SUP] copies/reaction] was significantly lower as compared to DDV [6.3 × 10[SUP]5[/SUP] copies/reaction, P = 0.005] and UnV [6.6 × 10[SUP]5[/SUP] copies/reaction, P = 0.001] groups. The rate of decline of SARS CoV-2 viral load in the initial 5 days of PCR positivity was significantly higher in SDV as compared to that in DDV (Mean log decline 0.39 vs. 0.19; P < 0.001). This was possibly due to interference of adenoviral immunity of first dose of adenovirus-vectored vaccine in double-dose vaccinated HCWs who had received vaccines within a shorter interval (<6 weeks).
. 2024 Feb 14;81(4):95.
doi: 10.1007/s00284-023-03603-7. Rapid Decline of SARS-CoV-2 Viral Load in Single vs. Double-Dose (Short-Interval <6 Weeks) ChAdOx nCoV-19 Vaccinated Health-Care Workers
Arnab Ghosh[SUP] #[/SUP][SUP] 1 [/SUP], Poonam Kanta[SUP] #[/SUP][SUP] 1 [/SUP], Manisha Ramola[SUP] 1 [/SUP], Ritin Mohindra[SUP] 2 [/SUP], Kapil Goyal[SUP] 1 [/SUP], Roop Kishore[SUP] 2 [/SUP], Vikas Suri[SUP] 2 [/SUP], P V M Lakshmi[SUP] 3 [/SUP], Chanderkanta Chauhan[SUP] 3 [/SUP], Manisha Sharma[SUP] 3 [/SUP], Partha Rakshit[SUP] 4 [/SUP], Kalaiarasan Ponnusamy[SUP] 4 [/SUP], Tanzin Dikid[SUP] 4 [/SUP], Mini P Singh[SUP] 5 [/SUP]
Affiliations
- PMID: 38353761
- DOI: 10.1007/s00284-023-03603-7
The present work was carried out during the emergence of Delta Variant of Concern (VoC) and aimed to study the change in SARS CoV-2 viral load in Covishield vaccinated asymptomatic/mildly symptomatic health-care workers (HCWs) to find out the optimum isolation period. The SARS CoV-2 viral load was carried out in sequential samples of 55 eligible HCWs which included unvaccinated (UnV; n = 11), single-dose vaccinated (SDV, n = 20) and double-dose vaccinated [DDV, n = 24; short-interval (<6 weeks)] subjects. The mean load of envelope (E) gene on day 5 in SDV [0.42 × 10[SUP]5[/SUP] copies/reaction] was significantly lower as compared to DDV [6.3 × 10[SUP]5[/SUP] copies/reaction, P = 0.005] and UnV [6.6 × 10[SUP]5[/SUP] copies/reaction, P = 0.001] groups. The rate of decline of SARS CoV-2 viral load in the initial 5 days of PCR positivity was significantly higher in SDV as compared to that in DDV (Mean log decline 0.39 vs. 0.19; P < 0.001). This was possibly due to interference of adenoviral immunity of first dose of adenovirus-vectored vaccine in double-dose vaccinated HCWs who had received vaccines within a shorter interval (<6 weeks).