tetano
Editor, Senior Moderator
Published ahead of print 19 March 2014, doi: 10.1128/CVI.00790-13 CVI.00790-13
Humans and ferrets with prior H1N1 influenza virus infections do not exhibit evidence of original antigenic sin after infection or vaccination with the 2009 pandemic H1N1 virus
Christopher D. O?Donnella,
Amber Wrighta,
Leatrice Vogela,
Kobporn Boonnaka,
John J. Treanorb and
Kanta Subbaraoa#
Laboratory of Infectious Diseases, NIAID, Bethesda, MD, USAa
Department of Medicine, University of Rochester Medical Center, Rochester, NY, USAb
ABSTRACT
The hypothesis of original antigenic sin (OAS) states that the imprint established by an individual's first influenza infection governs the antibody response thereafter. Subsequent influenza virus infections result in an antibody response against the original infecting virus, impairing the immune response against a newer influenza virus. The purpose of our study was to seek evidence of OAS after infection or vaccination with the 2009 pandemic H1N1 (2009 pH1N1) virus in ferrets and humans that had prior H1N1 infections with viruses of variable antigenic distance from the 2009 pH1N1 virus, including viruses from 1935 through 1999. In ferrets, seasonal H1N1 priming did not diminish the antibody response to infection or vaccination with the 2009 pH1N1 virus, nor did it diminish the T-cell response, indicating the absence of OAS in seasonal H1N1-virus primed ferrets. Analysis of paired samples of human sera taken before and after vaccination with a monovalent inactivated 2009 pH1N1 vaccine showed a significantly greater fold-rise in antibody titer against the 2009 pH1N1 virus compared to H1N1 viruses that circulated during the childhood of each subject. Thus, prior experience with H1N1 viruses did not result in an impairment of the antibody response against the 2009 pH1N1 vaccine. Our data from ferrets and humans suggest that prior exposure to H1N1 viruses did not impair the immune response against the 2009 pH1N1 virus.
http://cvi.asm.org/content/early/20...id=1&usestrictdates=yes&resourcetype=HWCIT&ct
Humans and ferrets with prior H1N1 influenza virus infections do not exhibit evidence of original antigenic sin after infection or vaccination with the 2009 pandemic H1N1 virus
Christopher D. O?Donnella,
Amber Wrighta,
Leatrice Vogela,
Kobporn Boonnaka,
John J. Treanorb and
Kanta Subbaraoa#
Laboratory of Infectious Diseases, NIAID, Bethesda, MD, USAa
Department of Medicine, University of Rochester Medical Center, Rochester, NY, USAb
ABSTRACT
The hypothesis of original antigenic sin (OAS) states that the imprint established by an individual's first influenza infection governs the antibody response thereafter. Subsequent influenza virus infections result in an antibody response against the original infecting virus, impairing the immune response against a newer influenza virus. The purpose of our study was to seek evidence of OAS after infection or vaccination with the 2009 pandemic H1N1 (2009 pH1N1) virus in ferrets and humans that had prior H1N1 infections with viruses of variable antigenic distance from the 2009 pH1N1 virus, including viruses from 1935 through 1999. In ferrets, seasonal H1N1 priming did not diminish the antibody response to infection or vaccination with the 2009 pH1N1 virus, nor did it diminish the T-cell response, indicating the absence of OAS in seasonal H1N1-virus primed ferrets. Analysis of paired samples of human sera taken before and after vaccination with a monovalent inactivated 2009 pH1N1 vaccine showed a significantly greater fold-rise in antibody titer against the 2009 pH1N1 virus compared to H1N1 viruses that circulated during the childhood of each subject. Thus, prior experience with H1N1 viruses did not result in an impairment of the antibody response against the 2009 pH1N1 vaccine. Our data from ferrets and humans suggest that prior exposure to H1N1 viruses did not impair the immune response against the 2009 pH1N1 virus.
http://cvi.asm.org/content/early/20...id=1&usestrictdates=yes&resourcetype=HWCIT&ct