tetano
Editor, Senior Moderator
Microbiol Immunol. 2012 Jun 26. doi: 10.1111/j.1348-0421.2012.00489.x. [Epub ahead of print]
Cytokine and chemokine responses in pediatric patients with severe pneumonia associated with pandemic A/H1N1/2009 influenza virus.
Matsumoto Y, Kawamura Y, Nakai H, Sugata K, Yoshikawa A, Ihira M, Ohashi M, Kato T, Yoshikawa T.
Source
Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan, Faculty of Clinical Engineering, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan, Department of Pediatrics, Toyokawa Municipal, Toyokawa, Aichi, Japan.
Abstract
High incidence of severe pneumonia and leukocytosis were characteristic clinical findings in pediatric patients with pandemic A/H1N1/2009 influenza virus infection. Aim of this study was to elucidate role of cytokines and chemokines in complicating pneumonia and leukocytosis in patients with pandemic A/H1N1/2009 influenza virus infection. Forty seven patients with pandemic A/H1N1/2009 influenza virus infection were enrolled in this study. The expression of interleukin (IL)-10 (P= 0.027) and IL-5 (P= 0.014) were significantly higher in patients with pneumonia than those without pneumonia. Additionally, serum concentrations of interferon-γ (P= 0.009), tumor necrosis factor-α (P= 0.01), IL-4 (P= 0.024), and IL-2 (P= 0.012) were significantly lower in the pneumonia patients with neutrophilic leukocytosis than those without neutrophilic leukocytosis. In five serum chemokine concentrations, only IL-8 was significantly lower in pneumonia patients with neutrophilic leukocytosis than those without leukocytosis (P= 0.001). These cytokines and chemokines may play important role in pathogenesis of childhood pneumonia associated with A/H1N1/2009 influenza virus infection.
? 2012 The Societies and Blackwell Publishing Asia Pty Ltd.
PMID:
22734496
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22734496
Cytokine and chemokine responses in pediatric patients with severe pneumonia associated with pandemic A/H1N1/2009 influenza virus.
Matsumoto Y, Kawamura Y, Nakai H, Sugata K, Yoshikawa A, Ihira M, Ohashi M, Kato T, Yoshikawa T.
Source
Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan, Faculty of Clinical Engineering, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan, Department of Pediatrics, Toyokawa Municipal, Toyokawa, Aichi, Japan.
Abstract
High incidence of severe pneumonia and leukocytosis were characteristic clinical findings in pediatric patients with pandemic A/H1N1/2009 influenza virus infection. Aim of this study was to elucidate role of cytokines and chemokines in complicating pneumonia and leukocytosis in patients with pandemic A/H1N1/2009 influenza virus infection. Forty seven patients with pandemic A/H1N1/2009 influenza virus infection were enrolled in this study. The expression of interleukin (IL)-10 (P= 0.027) and IL-5 (P= 0.014) were significantly higher in patients with pneumonia than those without pneumonia. Additionally, serum concentrations of interferon-γ (P= 0.009), tumor necrosis factor-α (P= 0.01), IL-4 (P= 0.024), and IL-2 (P= 0.012) were significantly lower in the pneumonia patients with neutrophilic leukocytosis than those without neutrophilic leukocytosis. In five serum chemokine concentrations, only IL-8 was significantly lower in pneumonia patients with neutrophilic leukocytosis than those without leukocytosis (P= 0.001). These cytokines and chemokines may play important role in pathogenesis of childhood pneumonia associated with A/H1N1/2009 influenza virus infection.
? 2012 The Societies and Blackwell Publishing Asia Pty Ltd.
PMID:
22734496
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22734496