tetano
Editor, Senior Moderator
Allergy Asthma Immunol Res. 2020 Feb;12(2):359-363. doi: 10.4168/aair.2020.12.2.359. [h=1]Delayed-Onset Anaphylaxis Caused by IgE Response to Influenza Vaccination.[/h]
Kim MJ[SUP]1,[/SUP][SUP]2[/SUP], Shim DH[SUP]2[/SUP], Cha HR[SUP]2[/SUP], Kim CB[SUP]2[/SUP], Kim SY[SUP]1[/SUP], Park JH[SUP]2[/SUP], Sohn MH[SUP]1[/SUP], Lee JM[SUP]3[/SUP], Kim KW[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza vaccine-associated anaphylaxis is a very rare allergic reaction to vaccines, but the most concerning and life-threatening adverse reaction. Although the safety of influenza vaccines has been well documented, occasional cases of anaphylaxis in vaccinated patients have been reported. In this study, we analyzed the immunoglobulin E (IgE) response to whole influenza vaccines in a pediatric case of delayed-onset anaphylaxis after influenza vaccination. The patient showed elevated specific IgE levels against whole influenza vaccines, especially with split virion from egg-based manufacturing process. Specific IgE levels to influenza vaccines showed decreased over. We evaluated a causal relationship between influenza vaccine and anaphylaxis event by enzyme-linked immunosorbent assay. Delayed-onset anaphylaxis after influenza vaccination can occur in children without predisposing allergic diseases. In addition, the results suggested that formulation and production system of influenza vaccines could affect the probability of severe allergic reaction to vaccines.
Copyright ? 2020 The Korean Academy of Asthma, Allergy and Clinical Immunology ? The Korean Academy of Pediatric Allergy and Respiratory Disease.
[h=4]KEYWORDS:[/h] Anaphylaxis; delayed hypersensitivity; drug hypersensitivity; immunoglobulin E; influenza; vaccination; vaccines
PMID: 32009327 DOI: 10.4168/aair.2020.12.2.359
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Kim MJ[SUP]1,[/SUP][SUP]2[/SUP], Shim DH[SUP]2[/SUP], Cha HR[SUP]2[/SUP], Kim CB[SUP]2[/SUP], Kim SY[SUP]1[/SUP], Park JH[SUP]2[/SUP], Sohn MH[SUP]1[/SUP], Lee JM[SUP]3[/SUP], Kim KW[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza vaccine-associated anaphylaxis is a very rare allergic reaction to vaccines, but the most concerning and life-threatening adverse reaction. Although the safety of influenza vaccines has been well documented, occasional cases of anaphylaxis in vaccinated patients have been reported. In this study, we analyzed the immunoglobulin E (IgE) response to whole influenza vaccines in a pediatric case of delayed-onset anaphylaxis after influenza vaccination. The patient showed elevated specific IgE levels against whole influenza vaccines, especially with split virion from egg-based manufacturing process. Specific IgE levels to influenza vaccines showed decreased over. We evaluated a causal relationship between influenza vaccine and anaphylaxis event by enzyme-linked immunosorbent assay. Delayed-onset anaphylaxis after influenza vaccination can occur in children without predisposing allergic diseases. In addition, the results suggested that formulation and production system of influenza vaccines could affect the probability of severe allergic reaction to vaccines.
Copyright ? 2020 The Korean Academy of Asthma, Allergy and Clinical Immunology ? The Korean Academy of Pediatric Allergy and Respiratory Disease.
[h=4]KEYWORDS:[/h] Anaphylaxis; delayed hypersensitivity; drug hypersensitivity; immunoglobulin E; influenza; vaccination; vaccines
PMID: 32009327 DOI: 10.4168/aair.2020.12.2.359
Free full text