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Depletion of Susceptibles Bias in Analyses of Intra-season Waning of Influenza Vaccine Effectiveness

tetano

Editor, Senior Moderator
Clin Infect Dis. 2019 Jul 28. pii: ciz706. doi: 10.1093/cid/ciz706. [Epub ahead of print]
[h=1]Depletion of Susceptibles Bias in Analyses of Intra-season Waning of Influenza Vaccine Effectiveness.[/h] Ray GT[SUP]1[/SUP], Lewis N[SUP]1[/SUP], Klein NP[SUP]1[/SUP], Daley MF[SUP]2[/SUP], Lipsitch M[SUP]3[/SUP], Fireman B[SUP]1[/SUP].
[h=3]Author information[/h]

[h=3]Abstract[/h] Bias arises in studies of waning vaccine effectiveness when higher-risk individuals are depleted from the population at-risk, at different rates between study groups. We examine how this bias arises and how it can be avoided. Reanalysis of data from California confirms a finding of intra-season waning of influenza vaccine effectiveness.
? The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.


[h=4]KEYWORDS:[/h] Depletion-of-susceptibles; bias; influenza; vaccine effectiveness; waning

PMID: 31351439 DOI: 10.1093/cid/ciz706
 
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