tetano
Editor, Senior Moderator
Dermatol Ther
. 2022 Mar 20;e15464.
doi: 10.1111/dth.15464. Online ahead of print.
Generalized erythrodermic psoriasis triggered by vaccination against severe acute respiratory syndrome coronavirus 2
Tong Ba Tran[SUP] 1 [/SUP], Nhi Thi Uyen Pham[SUP] 1 [/SUP], Huy Ngoc Phan[SUP] 1 [/SUP], Hao Trong Nguyen[SUP] 1 [/SUP]
Affiliations
Abstract
Generalized erythrodermic psoriasis (GEP) is a rare and potentially life-threatening variant of psoriasis. Possible triggers that have been identified to date include poorly controlled psoriasis, medications, abrupt discontinuation of anti-psoriatic treatment, and underlying systemic illnesses. However, vaccines have rarely been reported to exacerbate GEP. Herein, we report 2 unique cases with GEP exacerbated following a dose of the BNT162b2 mRNA vaccine for COVID-19 (as their second dose, the first being the mRNA-1273 vaccine). Based on our observations and a literature review, vaccination was considered the most likely trigger of GEP due to the close temporal relationship between the second vaccination and the onset of GEP. This article is protected by copyright. All rights reserved.
Keywords: BNT162b2 vaccine; COVID-19; SARS-CoV-2 vaccination; generalized erythrodermic psoriasis; mRNA-1273 vaccine.
. 2022 Mar 20;e15464.
doi: 10.1111/dth.15464. Online ahead of print.
Generalized erythrodermic psoriasis triggered by vaccination against severe acute respiratory syndrome coronavirus 2
Tong Ba Tran[SUP] 1 [/SUP], Nhi Thi Uyen Pham[SUP] 1 [/SUP], Huy Ngoc Phan[SUP] 1 [/SUP], Hao Trong Nguyen[SUP] 1 [/SUP]
Affiliations
- PMID: 35306720
- DOI: 10.1111/dth.15464
Abstract
Generalized erythrodermic psoriasis (GEP) is a rare and potentially life-threatening variant of psoriasis. Possible triggers that have been identified to date include poorly controlled psoriasis, medications, abrupt discontinuation of anti-psoriatic treatment, and underlying systemic illnesses. However, vaccines have rarely been reported to exacerbate GEP. Herein, we report 2 unique cases with GEP exacerbated following a dose of the BNT162b2 mRNA vaccine for COVID-19 (as their second dose, the first being the mRNA-1273 vaccine). Based on our observations and a literature review, vaccination was considered the most likely trigger of GEP due to the close temporal relationship between the second vaccination and the onset of GEP. This article is protected by copyright. All rights reserved.
Keywords: BNT162b2 vaccine; COVID-19; SARS-CoV-2 vaccination; generalized erythrodermic psoriasis; mRNA-1273 vaccine.