tetano
Editor, Senior Moderator
J Clin Virol. 2015 Nov 28;74:50-53. doi: 10.1016/j.jcv.2015.11.036. [Epub ahead of print]
[h=1]Detection of influenza C virus but not influenza D virus in Scottish respiratory samples.[/h] Smith DB[SUP]1[/SUP], Gaunt ER[SUP]2[/SUP], Digard P[SUP]2[/SUP], Templeton K[SUP]3[/SUP], Simmonds P[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] A newly proposed genus of influenza virus (influenza D) is associated with respiratory disease in pigs and cattle. The novel virus is most closely related to human influenza C virus and can infect ferrets but infection has not been reported in humans.
[h=4]OBJECTIVES:[/h] To ascertain if influenza D virus can be detected retrospectively in patient respiratory samples.
[h=4]STUDY DESIGN:[/h] 3300 human respiratory samples from Edinburgh, Scotland, covering the period 2006-2008, were screened in pools of 10 by RT-PCR using primers capable of detecting both influenza C and D viruses.
[h=4]RESULTS:[/h] Influenza D was not detected in any sample. Influenza C was present in 6 samples (0.2%), compared with frequencies of 3.3% and 0.9% for influenza A and B viruses from RT-PCR testing of respiratory samples over the same period. Influenza C virus was detected in samples from individuals <2 years or >45 years old, with cases occurring throughout the year. Phylogenetic analysis of nearly complete sequences of all seven segments revealed the presence of multiple, reassortant lineages.
[h=4]CONCLUSION:[/h] We were unable to detect viruses related to influenza D virus in human respiratory samples. Influenza C virus was less prevalent than influenza A and B viruses, was associated with mild disease in the young (<2 years) and old (>45 years) and comprised multiple, reassortant lineages. Inclusion of influenza C virus as part of a diagnostic testing panel for respiratory infections would be of limited additional value.
Copyright ? 2015 Z. Published by Elsevier B.V. All rights reserved.
[h=4]KEYWORDS:[/h] Influenza C virus; Respiratory disease
PMID: 26655269 [PubMed - as supplied by publisher]
[h=1]Detection of influenza C virus but not influenza D virus in Scottish respiratory samples.[/h] Smith DB[SUP]1[/SUP], Gaunt ER[SUP]2[/SUP], Digard P[SUP]2[/SUP], Templeton K[SUP]3[/SUP], Simmonds P[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] A newly proposed genus of influenza virus (influenza D) is associated with respiratory disease in pigs and cattle. The novel virus is most closely related to human influenza C virus and can infect ferrets but infection has not been reported in humans.
[h=4]OBJECTIVES:[/h] To ascertain if influenza D virus can be detected retrospectively in patient respiratory samples.
[h=4]STUDY DESIGN:[/h] 3300 human respiratory samples from Edinburgh, Scotland, covering the period 2006-2008, were screened in pools of 10 by RT-PCR using primers capable of detecting both influenza C and D viruses.
[h=4]RESULTS:[/h] Influenza D was not detected in any sample. Influenza C was present in 6 samples (0.2%), compared with frequencies of 3.3% and 0.9% for influenza A and B viruses from RT-PCR testing of respiratory samples over the same period. Influenza C virus was detected in samples from individuals <2 years or >45 years old, with cases occurring throughout the year. Phylogenetic analysis of nearly complete sequences of all seven segments revealed the presence of multiple, reassortant lineages.
[h=4]CONCLUSION:[/h] We were unable to detect viruses related to influenza D virus in human respiratory samples. Influenza C virus was less prevalent than influenza A and B viruses, was associated with mild disease in the young (<2 years) and old (>45 years) and comprised multiple, reassortant lineages. Inclusion of influenza C virus as part of a diagnostic testing panel for respiratory infections would be of limited additional value.
Copyright ? 2015 Z. Published by Elsevier B.V. All rights reserved.
[h=4]KEYWORDS:[/h] Influenza C virus; Respiratory disease
PMID: 26655269 [PubMed - as supplied by publisher]