tetano
Editor, Senior Moderator
Diabetes Care
. 2022 Jan 17;dc210969.
doi: 10.2337/dc21-0969. Online ahead of print.
Incidence of Type 1 Diabetes in Children and Adolescents During the COVID-19 Pandemic in Germany: Results From the DPV Registry
Clemens Kamrath[SUP] 1 [/SUP], Joachim Rosenbauer[SUP] 2 3 [/SUP], Alexander J Eckert[SUP] 3 4 [/SUP], Kai Siedler[SUP] 5 [/SUP], Heike Bartelt[SUP] 6 [/SUP], Daniela Klose[SUP] 7 [/SUP], Marina Sindichakis[SUP] 8 [/SUP], Silke Herrlinger[SUP] 9 [/SUP], Valentina Lahn[SUP] 10 [/SUP], Reinhard W Holl[SUP] 3 4 [/SUP]
Affiliations
Abstract
Objective: The aim of this study was to investigate the incidence of type 1 diabetes in children and adolescents during the coronavirus disease 2019 (COVID-19) pandemic in Germany compared with previous years.
Research design and methods: Based on data from the multicenter German Diabetes Prospective Follow-up Registry, we analyzed the incidence of type 1 diabetes per 100,000 patient-years in children and adolescents from 1 January 2020 through 30 June 2021. Using Poisson regression models, expected incidences for 2020/21 were estimated based on the data from 2011 to 2019 and compared with observed incidences in 2020/21 by estimating incidence rate ratios (IRRs) with 95% CIs.
Results: From 1 January 2020 to 30 June 2021, 5,162 children and adolescents with new-onset type 1 diabetes in Germany were registered. The observed incidence in 2020/21 was significantly higher than the expected incidence (24.4 [95% CI 23.6-25.2] vs. 21.2 [20.5-21.9]; IRR 1.15 [1.10-1.20]; P < 0.001). IRRs were significantly elevated in June 2020 (IRR 1.43 [1.07-1.90]; P = 0.003), July 2020 (IRR 1.48 [1.12-1.96]; P < 0.001), March 2021 (IRR 1.29 [1.01-1.65]; P = 0.028), and June 2021 (IRR 1.39 [1.04-1.85]; P = 0.010).
Conclusions: A significant increase in the incidence of type 1 diabetes in children was observed during the COVID-19 pandemic, with a delay in the peak incidence of type 1 diabetes by ∼3 months after the peak COVID-19 incidence and also after pandemic containment measures. The underlying causes are yet unknown. However, indirect rather than direct effects of the pandemic are more likely to be the cause.
. 2022 Jan 17;dc210969.
doi: 10.2337/dc21-0969. Online ahead of print.
Incidence of Type 1 Diabetes in Children and Adolescents During the COVID-19 Pandemic in Germany: Results From the DPV Registry
Clemens Kamrath[SUP] 1 [/SUP], Joachim Rosenbauer[SUP] 2 3 [/SUP], Alexander J Eckert[SUP] 3 4 [/SUP], Kai Siedler[SUP] 5 [/SUP], Heike Bartelt[SUP] 6 [/SUP], Daniela Klose[SUP] 7 [/SUP], Marina Sindichakis[SUP] 8 [/SUP], Silke Herrlinger[SUP] 9 [/SUP], Valentina Lahn[SUP] 10 [/SUP], Reinhard W Holl[SUP] 3 4 [/SUP]
Affiliations
- PMID: 35043145
- DOI: 10.2337/dc21-0969
Abstract
Objective: The aim of this study was to investigate the incidence of type 1 diabetes in children and adolescents during the coronavirus disease 2019 (COVID-19) pandemic in Germany compared with previous years.
Research design and methods: Based on data from the multicenter German Diabetes Prospective Follow-up Registry, we analyzed the incidence of type 1 diabetes per 100,000 patient-years in children and adolescents from 1 January 2020 through 30 June 2021. Using Poisson regression models, expected incidences for 2020/21 were estimated based on the data from 2011 to 2019 and compared with observed incidences in 2020/21 by estimating incidence rate ratios (IRRs) with 95% CIs.
Results: From 1 January 2020 to 30 June 2021, 5,162 children and adolescents with new-onset type 1 diabetes in Germany were registered. The observed incidence in 2020/21 was significantly higher than the expected incidence (24.4 [95% CI 23.6-25.2] vs. 21.2 [20.5-21.9]; IRR 1.15 [1.10-1.20]; P < 0.001). IRRs were significantly elevated in June 2020 (IRR 1.43 [1.07-1.90]; P = 0.003), July 2020 (IRR 1.48 [1.12-1.96]; P < 0.001), March 2021 (IRR 1.29 [1.01-1.65]; P = 0.028), and June 2021 (IRR 1.39 [1.04-1.85]; P = 0.010).
Conclusions: A significant increase in the incidence of type 1 diabetes in children was observed during the COVID-19 pandemic, with a delay in the peak incidence of type 1 diabetes by ∼3 months after the peak COVID-19 incidence and also after pandemic containment measures. The underlying causes are yet unknown. However, indirect rather than direct effects of the pandemic are more likely to be the cause.