tetano
Editor, Senior Moderator
Diabetes Metab Syndr
. 2020 May 8;14(4):671-677.
doi: 10.1016/j.dsx.2020.05.013. Online ahead of print.
Diabetes and Metabolic Syndrome as Risk Factors for COVID-19
Marko Marhl[SUP] 1 [/SUP], Vladimir Grubelnik[SUP] 2 [/SUP], Marša Magdič[SUP] 3 [/SUP], Rene Markovič[SUP] 4 [/SUP]
Affiliations
Abstract
Background and aims: Clinical evidence exists that patients with diabetes are at higher risk for Coronavirus disease 2019 (COVID-19). We investigated the physiological origins of this clinical observation linking diabetes with severity and adverse outcome of COVID-19.
Methods: Publication mining was applied to reveal common physiological contexts in which diabetes and COVID-19 have been investigated simultaneously. Overall, we have acquired 1,121,078 publications from PubMed in the time span between 01-01-2000 and 17-04-2020, and extracted knowledge graphs interconnecting the topics related to diabetes and COVID-19.
Results: The Data Mining revealed three pathophysiological pathways linking diabetes and COVID-19. The first pathway indicates a higher risk for COVID-19 because of a dysregulation of Angiotensin-converting enzyme 2. The other two important physiological links between diabetes and COVID-19 are liver dysfunction and chronic systemic inflammation. A deep network analysis has suggested clinical biomarkers predicting the higher risk: Hypertension, elevated serum Alanine aminotransferase, high Interleukin-6, and low Lymphocytes count.
Conclusions: The revealed biomarkers can be applied directly in clinical practice. For newly infected patients, the medical history needs to be checked for evidence of a long-term, chronic dysregulation of these biomarkers. In particular, patients with diabetes, but also those with prediabetic state, deserve special attention.
Keywords: ACE2; Hypertension; Inflammation; Liver dysfunction; SARS-Coronavirus-2.
. 2020 May 8;14(4):671-677.
doi: 10.1016/j.dsx.2020.05.013. Online ahead of print.
Diabetes and Metabolic Syndrome as Risk Factors for COVID-19
Marko Marhl[SUP] 1 [/SUP], Vladimir Grubelnik[SUP] 2 [/SUP], Marša Magdič[SUP] 3 [/SUP], Rene Markovič[SUP] 4 [/SUP]
Affiliations
- PMID: 32438331
- DOI: 10.1016/j.dsx.2020.05.013
Abstract
Background and aims: Clinical evidence exists that patients with diabetes are at higher risk for Coronavirus disease 2019 (COVID-19). We investigated the physiological origins of this clinical observation linking diabetes with severity and adverse outcome of COVID-19.
Methods: Publication mining was applied to reveal common physiological contexts in which diabetes and COVID-19 have been investigated simultaneously. Overall, we have acquired 1,121,078 publications from PubMed in the time span between 01-01-2000 and 17-04-2020, and extracted knowledge graphs interconnecting the topics related to diabetes and COVID-19.
Results: The Data Mining revealed three pathophysiological pathways linking diabetes and COVID-19. The first pathway indicates a higher risk for COVID-19 because of a dysregulation of Angiotensin-converting enzyme 2. The other two important physiological links between diabetes and COVID-19 are liver dysfunction and chronic systemic inflammation. A deep network analysis has suggested clinical biomarkers predicting the higher risk: Hypertension, elevated serum Alanine aminotransferase, high Interleukin-6, and low Lymphocytes count.
Conclusions: The revealed biomarkers can be applied directly in clinical practice. For newly infected patients, the medical history needs to be checked for evidence of a long-term, chronic dysregulation of these biomarkers. In particular, patients with diabetes, but also those with prediabetic state, deserve special attention.
Keywords: ACE2; Hypertension; Inflammation; Liver dysfunction; SARS-Coronavirus-2.