tetano
Editor, Senior Moderator
Diagn Microbiol Infect Dis
. 2021 Sep 9;101(4):115537.
doi: 10.1016/j.diagmicrobio.2021.115537. Online ahead of print.
Kinetics of anti-SARS-CoV-2 IgG antibody levels and potential influential factors in subjects with COVID-19: A 11-month follow-up study
Huanyuan Luo[SUP] 1 [/SUP], Dorothée Camilleri[SUP] 2 [/SUP], Ibon Garitaonandia[SUP] 3 [/SUP], Dilshat Djumanov[SUP] 2 [/SUP], Tao Chen[SUP] 1 [/SUP], Ulrike Lorch[SUP] 2 [/SUP], Jörg Täubel[SUP] 4 [/SUP], Duolao Wang[SUP] 5 [/SUP]
Affiliations
Abstract
We aim to study kinetics of anti-SARS-CoV-2 IgG antibody levels in subjects with COVID-19 for up to 11 months and the potential influential factors. The study was a prospective longitudinal study. The analyses were based on 77 serum/plasma samples with a mean of 4 samples per participant (range 1 - 18) in 20 participants with at least one positive Polymerase Chain Reaction testing result from 19 March 2020 up to 10 February 2021. Among the subjects (median age 34.5 years, 65% male), IgG level declined with the follow-up time (per month; geometric mean ratio [GMR] 0.73; 95% CI, 0.72 - 0.74). In a small sample of subjects from the general population with COVID-19, IgG levels declined non-linearly from month 2 to 11 with individual heterogeneity in quantity and changing speed and may be associated with gender, race and the loss of smell and taste.
Keywords: COVID-19; IgG; SARS-CoV-2; antibody; coronavirus; kinetics.
. 2021 Sep 9;101(4):115537.
doi: 10.1016/j.diagmicrobio.2021.115537. Online ahead of print.
Kinetics of anti-SARS-CoV-2 IgG antibody levels and potential influential factors in subjects with COVID-19: A 11-month follow-up study
Huanyuan Luo[SUP] 1 [/SUP], Dorothée Camilleri[SUP] 2 [/SUP], Ibon Garitaonandia[SUP] 3 [/SUP], Dilshat Djumanov[SUP] 2 [/SUP], Tao Chen[SUP] 1 [/SUP], Ulrike Lorch[SUP] 2 [/SUP], Jörg Täubel[SUP] 4 [/SUP], Duolao Wang[SUP] 5 [/SUP]
Affiliations
- PMID: 34619569
- DOI: 10.1016/j.diagmicrobio.2021.115537
Abstract
We aim to study kinetics of anti-SARS-CoV-2 IgG antibody levels in subjects with COVID-19 for up to 11 months and the potential influential factors. The study was a prospective longitudinal study. The analyses were based on 77 serum/plasma samples with a mean of 4 samples per participant (range 1 - 18) in 20 participants with at least one positive Polymerase Chain Reaction testing result from 19 March 2020 up to 10 February 2021. Among the subjects (median age 34.5 years, 65% male), IgG level declined with the follow-up time (per month; geometric mean ratio [GMR] 0.73; 95% CI, 0.72 - 0.74). In a small sample of subjects from the general population with COVID-19, IgG levels declined non-linearly from month 2 to 11 with individual heterogeneity in quantity and changing speed and may be associated with gender, race and the loss of smell and taste.
Keywords: COVID-19; IgG; SARS-CoV-2; antibody; coronavirus; kinetics.