tetano
Editor, Senior Moderator
Virology. 2019 Jan 15;530:11-18. doi: 10.1016/j.virol.2019.01.016. [Epub ahead of print]
[h=1]Different pathogenicity of two strains of clade 2.3.4.4c H5N6 highly pathogenic avian influenza viruses bearing different PA and NS gene in domestic ducks.[/h] Kwon JH[SUP]1[/SUP], Noh JY[SUP]1[/SUP], Jeong JH[SUP]1[/SUP], Jeong S[SUP]1[/SUP], Lee SH[SUP]1[/SUP], Kim YJ[SUP]1[/SUP], Yuk SS[SUP]1[/SUP], Lee DH[SUP]2[/SUP], Bae YC[SUP]3[/SUP], Park SC[SUP]3[/SUP], Lee KH[SUP]3[/SUP], Lee EK[SUP]3[/SUP], Lee YN[SUP]3[/SUP], Lee YJ[SUP]3[/SUP], Song CS[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] H5Nx clade 2.3.4.4 highly pathogenic avian influenza viruses (HPAIVs) have been disseminated to wide geographic regions since 2014. In 2016, five distinct genotypes (C-1 to C-5) of clade 2.3.4.4c H5N6 HPAIVs were detected in South Korea. In this study, we evaluated the pathogenicity, susceptibility to infection, and transmissibility of the two strains representing the C-1 and C-4 genotypes of the H5N6 viruses, which have different PA and NS gene, in domestic ducks. Although the susceptibility to infection of domestic ducks to the two strains was similar, the C-4 genotype virus induced higher mortality in ducks than C-1 genotype virus. A higher titer of viral shedding were detected in ducks challenged with the C-4 genotype virus compared with the C-1 genotype virus. These results indicated that the reassortment of HPAIVs with prevailing low pathogenic avian influenza viruses could effect on the pathogenicity in ducks.
Copyright ? 2019. Published by Elsevier Inc.
[h=4]KEYWORDS:[/h] Domestic duck; H5N6; Highly pathogenic avian influenza virus; Pathogenicity; Reassortment
PMID: 30753976 DOI: 10.1016/j.virol.2019.01.016
[h=1]Different pathogenicity of two strains of clade 2.3.4.4c H5N6 highly pathogenic avian influenza viruses bearing different PA and NS gene in domestic ducks.[/h] Kwon JH[SUP]1[/SUP], Noh JY[SUP]1[/SUP], Jeong JH[SUP]1[/SUP], Jeong S[SUP]1[/SUP], Lee SH[SUP]1[/SUP], Kim YJ[SUP]1[/SUP], Yuk SS[SUP]1[/SUP], Lee DH[SUP]2[/SUP], Bae YC[SUP]3[/SUP], Park SC[SUP]3[/SUP], Lee KH[SUP]3[/SUP], Lee EK[SUP]3[/SUP], Lee YN[SUP]3[/SUP], Lee YJ[SUP]3[/SUP], Song CS[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] H5Nx clade 2.3.4.4 highly pathogenic avian influenza viruses (HPAIVs) have been disseminated to wide geographic regions since 2014. In 2016, five distinct genotypes (C-1 to C-5) of clade 2.3.4.4c H5N6 HPAIVs were detected in South Korea. In this study, we evaluated the pathogenicity, susceptibility to infection, and transmissibility of the two strains representing the C-1 and C-4 genotypes of the H5N6 viruses, which have different PA and NS gene, in domestic ducks. Although the susceptibility to infection of domestic ducks to the two strains was similar, the C-4 genotype virus induced higher mortality in ducks than C-1 genotype virus. A higher titer of viral shedding were detected in ducks challenged with the C-4 genotype virus compared with the C-1 genotype virus. These results indicated that the reassortment of HPAIVs with prevailing low pathogenic avian influenza viruses could effect on the pathogenicity in ducks.
Copyright ? 2019. Published by Elsevier Inc.
[h=4]KEYWORDS:[/h] Domestic duck; H5N6; Highly pathogenic avian influenza virus; Pathogenicity; Reassortment
PMID: 30753976 DOI: 10.1016/j.virol.2019.01.016