tetano
Editor, Senior Moderator
Clin Infect Dis. 2017 Mar 23. doi: 10.1093/cid/cix269. [Epub ahead of print]
[h=1]Differential Effects of Prior Influenza Exposures on H3N2 Cross-reactivity of Human Post-vaccination Sera.[/h] Xie H[SUP]1[/SUP], Li L[SUP]2[/SUP], Ye Z[SUP]1[/SUP], Li X[SUP]1[/SUP], Plant EP[SUP]1[/SUP], Zoueva O[SUP]1[/SUP], Zhao Y[SUP]1[/SUP], Jing X[SUP]1[/SUP], Lin Z[SUP]1[/SUP], Kawano T[SUP]1[/SUP], Chiang MJ[SUP]1[/SUP], Finch CL[SUP]1[/SUP], Kosikova M[SUP]1[/SUP], Zhang A[SUP]1[/SUP], Zhu Y[SUP]1[/SUP], Wan XF[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background.:[/h] Effectiveness of seasonal influenza vaccines mainly depends upon how well vaccine strains represent circulating viruses; mismatched strains can lead to reduced protection. Human have complex influenza exposure histories that increase with age, which may lead to different post-vaccination responses to emerging influenza variants. Recent observational studies also suggest prior vaccination may influence the performance of current seasonal vaccines.
[h=4]Methods.:[/h] To elucidate the effects of age and influenza pre-exposures on cross-reactivity of vaccination-induced human antibodies, we generated antigenic maps based on post-vaccination hemagglutination inhibition titers against representative H3 variants circulating during the 2015/16, 2014/15, and 2012/13 influenza seasons respectively.
[h=4]Results.:[/h] Antigenic maps determined using sera from subjects 18-64 and ≥65 years of age correlated well with each other but poorly with those determined using sera from children. Antigenic maps derived from human post-vaccination sera with H1 influenza pre-exposure also correlated poorly with those derived from sera with neither H1 nor type B influenza pre-exposure, and the correlation lessened considerably over time. In contrast, antigenic maps derived from human post-vaccination sera with only type B influenza pre-exposure consistently showed good correlation with those derived from sera with neither H1 nor type B influenza pre-exposure.
[h=4]Conclusions.:[/h] Our results suggest an age-specific difference in human post-vaccination responses. Our findings also suggest prior exposure to H1 or type B influenza may differentially affect cross-reactivity of vaccination-induced H3-specific hemagglutination inhibition antibody responses, and consequently might affect vaccine effectiveness. Our study highlights the need to study the impact of prior exposure on influenza vaccine performance.
[h=4]KEYWORDS:[/h] Antigenic Map; H3N2 Antibody Cross-reactivity; Prior Exposure; Seasonal Influenza Vaccine; Vaccine Strain Selection
PMID: 28369230 DOI: 10.1093/cid/cix269
[h=1]Differential Effects of Prior Influenza Exposures on H3N2 Cross-reactivity of Human Post-vaccination Sera.[/h] Xie H[SUP]1[/SUP], Li L[SUP]2[/SUP], Ye Z[SUP]1[/SUP], Li X[SUP]1[/SUP], Plant EP[SUP]1[/SUP], Zoueva O[SUP]1[/SUP], Zhao Y[SUP]1[/SUP], Jing X[SUP]1[/SUP], Lin Z[SUP]1[/SUP], Kawano T[SUP]1[/SUP], Chiang MJ[SUP]1[/SUP], Finch CL[SUP]1[/SUP], Kosikova M[SUP]1[/SUP], Zhang A[SUP]1[/SUP], Zhu Y[SUP]1[/SUP], Wan XF[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background.:[/h] Effectiveness of seasonal influenza vaccines mainly depends upon how well vaccine strains represent circulating viruses; mismatched strains can lead to reduced protection. Human have complex influenza exposure histories that increase with age, which may lead to different post-vaccination responses to emerging influenza variants. Recent observational studies also suggest prior vaccination may influence the performance of current seasonal vaccines.
[h=4]Methods.:[/h] To elucidate the effects of age and influenza pre-exposures on cross-reactivity of vaccination-induced human antibodies, we generated antigenic maps based on post-vaccination hemagglutination inhibition titers against representative H3 variants circulating during the 2015/16, 2014/15, and 2012/13 influenza seasons respectively.
[h=4]Results.:[/h] Antigenic maps determined using sera from subjects 18-64 and ≥65 years of age correlated well with each other but poorly with those determined using sera from children. Antigenic maps derived from human post-vaccination sera with H1 influenza pre-exposure also correlated poorly with those derived from sera with neither H1 nor type B influenza pre-exposure, and the correlation lessened considerably over time. In contrast, antigenic maps derived from human post-vaccination sera with only type B influenza pre-exposure consistently showed good correlation with those derived from sera with neither H1 nor type B influenza pre-exposure.
[h=4]Conclusions.:[/h] Our results suggest an age-specific difference in human post-vaccination responses. Our findings also suggest prior exposure to H1 or type B influenza may differentially affect cross-reactivity of vaccination-induced H3-specific hemagglutination inhibition antibody responses, and consequently might affect vaccine effectiveness. Our study highlights the need to study the impact of prior exposure on influenza vaccine performance.
[h=4]KEYWORDS:[/h] Antigenic Map; H3N2 Antibody Cross-reactivity; Prior Exposure; Seasonal Influenza Vaccine; Vaccine Strain Selection
PMID: 28369230 DOI: 10.1093/cid/cix269