tetano
Editor, Senior Moderator
Immunology. 2016 Feb 8. doi: 10.1111/imm.12594. [Epub ahead of print]
[h=1]Directed selection of influenza virus produces antigenic variants that match circulating human virus isolates and escape from vaccine mediated immune protection.[/h] DeDiego ML[SUP]1[/SUP], Anderson CS[SUP]1[/SUP], Yang H[SUP]2[/SUP], Holden-Wiltse J[SUP]2[/SUP], Fitzgerald T[SUP]3[/SUP], Treanor JJ[SUP]3[/SUP], Topham DJ[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza vaccination does not provide 100% protection from infection, partly due to antigenic drift of the HA protein. Low serum antibody titers increase risk of infection. To determine whether there were additional correlates of risk, we examined the relationship between human serum immunity and antigenic variation in seasonal H3N2 influenza viruses. Seasonal H3N2 vaccine strains grown in the presence of heterogeneous human or mono-specific ferret antisera selected variants with mutations in the HA antigenic sites. Surprisingly, circulating strains infecting human subjects in the same seasons displayed mutations in the same positions, although only in one case the change corresponded to the same aminoacid. Serum antibody titers were lower against both the in vitro selected and clinical isolates compared to the vaccine strains, suggesting that the mutations are relevant to vaccine failure. Antibody titers were also significantly lower in sera from infected subjects than in non-infected subjects, suggesting relatively poor responses to vaccination in the infected subjects. Collectively, the data suggest that risk from influenza infection is a result of poor response to vaccination, as well as encounter with drifted seasonal influenza virus antigenic variants. The results also show that directed selection under human immune pressure could reveal antigenic variants relevant to real world drifted viruses, helping in annual vaccine re-formulation. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] antigenic drift; circulating strains; hemagglutinin; human influenza virus; human influenza virus, antibody immune response; influenza specific antibodies; influenza virus vaccination; vaccine strain; vaccines
PMID: 26854888 [PubMed - as supplied by publisher]
[h=1]Directed selection of influenza virus produces antigenic variants that match circulating human virus isolates and escape from vaccine mediated immune protection.[/h] DeDiego ML[SUP]1[/SUP], Anderson CS[SUP]1[/SUP], Yang H[SUP]2[/SUP], Holden-Wiltse J[SUP]2[/SUP], Fitzgerald T[SUP]3[/SUP], Treanor JJ[SUP]3[/SUP], Topham DJ[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza vaccination does not provide 100% protection from infection, partly due to antigenic drift of the HA protein. Low serum antibody titers increase risk of infection. To determine whether there were additional correlates of risk, we examined the relationship between human serum immunity and antigenic variation in seasonal H3N2 influenza viruses. Seasonal H3N2 vaccine strains grown in the presence of heterogeneous human or mono-specific ferret antisera selected variants with mutations in the HA antigenic sites. Surprisingly, circulating strains infecting human subjects in the same seasons displayed mutations in the same positions, although only in one case the change corresponded to the same aminoacid. Serum antibody titers were lower against both the in vitro selected and clinical isolates compared to the vaccine strains, suggesting that the mutations are relevant to vaccine failure. Antibody titers were also significantly lower in sera from infected subjects than in non-infected subjects, suggesting relatively poor responses to vaccination in the infected subjects. Collectively, the data suggest that risk from influenza infection is a result of poor response to vaccination, as well as encounter with drifted seasonal influenza virus antigenic variants. The results also show that directed selection under human immune pressure could reveal antigenic variants relevant to real world drifted viruses, helping in annual vaccine re-formulation. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] antigenic drift; circulating strains; hemagglutinin; human influenza virus; human influenza virus, antibody immune response; influenza specific antibodies; influenza virus vaccination; vaccine strain; vaccines
PMID: 26854888 [PubMed - as supplied by publisher]