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http://www.clarin.com/sociedad/salud/Descubren-gripe-mato-adultos-sanos_0_385161530.html
Spanish to English translation
Discovered why the flu killed so many healthy adults
6/12/1910 Sometimes the organism may be confused with another virus and launch an inadequate defense.
Roman PorValeria
A flu team of scientists from Argentina and the United States discovered why the flu virus H1N1 led to the deaths of so many healthy people who were between 20 and 60. They found that the body triggers an inappropriate immune response against the virus that ends up killing the same person.
The discovery was made on samples from the lungs of patients who suffered influenza pandemic H1N1 last year, and were compared with samples from people who had died from the pandemic of 1957. The results of the study, published yesterday in the journal Nature Medicine, will be very useful for the future.
"This leads to the conclusion that people with no previous diseases that are severely affected by a pandemic could be addressed in future immune modulators to prevent mortality," he told Clarin a labor leader, Fernando Pollack, who heads Infant Foundation in Buenos Aires and is part of the Research of Vanderbilt University in Nashville, USA.
The finding was the result of a collaborative study between public and private institutions. Participants included researchers from the Institute and Elsa Savy Vilma Malbr?n Baumeister and doctors at the National Hospital Alejandro Posadas, the Cemic, Federico Abete Hospital Malvinas Argentinas Party and the Italian Hospital of Buenos Aires.
Flu usually strikes fatally over 65 years. But in cases of pandemics, such as that developed last year, people panicked to learn that many of those affected had no previous illnesses. "The reason for this situation was always in the minds of many scientists," says Pollack, who last year put together the team of investigators to arrive at an answer.
It was already known that people over 65 have special defenses because they had been exposed to pre-1957 pandemics. The kids were the most infected last year because their defenses were at zero. But the most serious were older than 20 years.
"What we found is that the body of patients killed by the H1N1 flu had meetings with the seasonal virus that circulated during the previous years. This meant that the agency was building a series of defenses. When the virus is influenza A H1N1, the immune system mistaking it for the other viruses. Unable to kill them, the body downloaded a specific complex that ended with the virus but also with the host himself, ie the human body, "said Argentine researcher.
When lung samples studied were affected by the pandemic influenza of 1957 in the U.S., also detected the presence of C4d protein, part of the complex immune system uses to carry out the attack against the virus. "This means that cases of pandemic influenza virus, the immune response of healthy young adults is excessive. That is why they are the most affected in most of the pandemics
Spanish to English translation
Discovered why the flu killed so many healthy adults
6/12/1910 Sometimes the organism may be confused with another virus and launch an inadequate defense.
Roman PorValeria
A flu team of scientists from Argentina and the United States discovered why the flu virus H1N1 led to the deaths of so many healthy people who were between 20 and 60. They found that the body triggers an inappropriate immune response against the virus that ends up killing the same person.
The discovery was made on samples from the lungs of patients who suffered influenza pandemic H1N1 last year, and were compared with samples from people who had died from the pandemic of 1957. The results of the study, published yesterday in the journal Nature Medicine, will be very useful for the future.
"This leads to the conclusion that people with no previous diseases that are severely affected by a pandemic could be addressed in future immune modulators to prevent mortality," he told Clarin a labor leader, Fernando Pollack, who heads Infant Foundation in Buenos Aires and is part of the Research of Vanderbilt University in Nashville, USA.
The finding was the result of a collaborative study between public and private institutions. Participants included researchers from the Institute and Elsa Savy Vilma Malbr?n Baumeister and doctors at the National Hospital Alejandro Posadas, the Cemic, Federico Abete Hospital Malvinas Argentinas Party and the Italian Hospital of Buenos Aires.
Flu usually strikes fatally over 65 years. But in cases of pandemics, such as that developed last year, people panicked to learn that many of those affected had no previous illnesses. "The reason for this situation was always in the minds of many scientists," says Pollack, who last year put together the team of investigators to arrive at an answer.
It was already known that people over 65 have special defenses because they had been exposed to pre-1957 pandemics. The kids were the most infected last year because their defenses were at zero. But the most serious were older than 20 years.
"What we found is that the body of patients killed by the H1N1 flu had meetings with the seasonal virus that circulated during the previous years. This meant that the agency was building a series of defenses. When the virus is influenza A H1N1, the immune system mistaking it for the other viruses. Unable to kill them, the body downloaded a specific complex that ended with the virus but also with the host himself, ie the human body, "said Argentine researcher.
When lung samples studied were affected by the pandemic influenza of 1957 in the U.S., also detected the presence of C4d protein, part of the complex immune system uses to carry out the attack against the virus. "This means that cases of pandemic influenza virus, the immune response of healthy young adults is excessive. That is why they are the most affected in most of the pandemics
