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Discussion thread IV - COVID-19 (new coronavirus)

Doctor shares useful tips for how to properly clean your groceries
COVID-19 PANDEMIC
by: Nexstar Media Wire

Posted: Mar 25, 2020 / 05:44 PM CDT / Updated: Mar 25, 2020 / 05:44 PM CDT

...
Once home, VanWingen recommends keeping your groceries outside your home, whether that be in the garage or car, for three days as he says coronavirus can live in the air for three hours and on plastic and metal surfaces for three days.

If you can’t wait, be ready to disinfect.

“Imagining that the groceries have some glitter on them, on the packaging and the bags,” VanWingen said when describing his surgical-like approach to disinfecting groceries. “Our goal is to not have any glitter at the end of this process in our house, on our hands, or more importantly on our face.”
...
https://wgntv.com/news/coronavirus/...ips-for-how-to-properly-clean-your-groceries/
 
Translation Google

China's epidemic fears resurgence? German expert: See you in a month

Date 25.03.2020
Author Wen Mu (comprehensive report)

Chinese official statistics show that the epidemic situation in China has eased significantly, but some people doubt whether the real numbers are as optimistic as the official report. Analysts are worried that Beijing will put economic development above the containment of the virus. Authoritative German experts point out that as life around China gradually returns to normal, perhaps the epidemic will return in a month.

(Voice of German in Chinese) Hubei province lifted travel restrictions in most areas on Wednesday, and people's lives gradually returned to normal. The number of confirmed cases in China has been decreasing in the past three weeks, and Wuhan has not found any new local cases for four consecutive days from March 18 to 21.

Although some public health experts and official Chinese figures have stated that China's epidemic situation has improved, many are wondering whether the numbers are as optimistic as officially reported as cities begin to rework. Some people have questioned the official near-zero additions. The New York Times reported that China first announced zero cases of local infection last week, but then Chinese social media circulated notice photos from some communities in Wuhan, which appeared to announce new cases.

"The Guardian" quoted a 26-year-old Chinese resident as saying: "I'm really worried that there are still many asymptomatic infected people in Wuhan. Everyone goes back to work and everyone gets infected." Another resident added "I don't believe (these numbers). This epidemic will not disappear so easily."

Some analysts pointed out that the Beijing government's initial efforts to suppress the epidemic-related information and rigorous review of public opinion have increased people's distrust of these figures. Ho-fung ****, a professor of political economy at Johns Hopkins University in the United States, said: "In December last year, in January this year, if there was no more credible and reliable the evidence is verified, and we really cannot trust the data released by the Chinese government. "

Expert: The epidemic will definitely make a comeback

The New York Times pointed out that China's officially confirmed cases only include patients who have both symptomatic virus tests and are positive. This approach differs from WHO guidance. WHO believes that all infected persons who test positive for the virus should be considered confirmed, regardless of whether they have symptoms. The media quoted epidemiologists as saying that resumption of travel, work, and daily life could return to the spread of the virus, even if there were no new cases of infection.

Some experts have warned that a new round of infection is inevitable in China. Professor Benjamin Cowling of the School of Public Health of the University of Hong Kong said in an interview with Deutsche Canton: "Everyone is alert to the outbreak of the second wave of outbreaks because China has already imported cases from abroad. When will a new wave of infection spread, It is only a matter of time when the number will rise and cause concern again. I don't know when China will break out again, but the epidemic will definitely appear again! "

Christian Drosten, a prominent virologist at the Charit? School of Medicine in Berlin, holds the same view, and the coronavirus expert is also considered to be one of the most important experts in German epidemic prevention. In an interview program aired on March 18, Drosten said of the slowdown in China ’s epidemic: "I think the number of people in China will rise again. We see that the number of people who return from Italy, the number of people who are quarantined, and not many, so as to avoid overseas input. At the same time, there are only 3 newly diagnosed people, and now no one will believe such data. Nowadays people are no longer isolated, their lives are gradually returning to normal, and the epidemic will come back. We can wait for a month, this after a wave of deaths has passed, the number of infections will rise again. The exact number of deaths is not easy to hide. I think we will see what the situation is like in China in a month. "

Economic benefits matter most?

The Kyodo News reported last weekend that a local doctor in Wuhan stated that the number of infected cases had been manipulated before Xi Jinping went to Hubei earlier this month.

Wang Dan, an economic analyst, told Deguang that China is facing a severe recession in the export and retail industries, the service industry in large cities is still experiencing a recession, and many companies have not yet operated normally. The Chinese leadership wants to speed up, but also encounters some resistance: "Chinese leaders are doing everything they can to get people back to work. But governments everywhere have good reasons for people to wait for factories to restart and run. Because if the number of infected people rises again, , their political career is over. "

Some analysts worry that Beijing's top leaders will put the restart of the economy on top of containing the virus. The Guardian quoted Victor Shih, an associate professor of Chinese politics at the University of California, San Diego, as saying that the Chinese leadership attaches great importance to restoring the economy: "One way to restore the economy without causing panic is to cover up the true situation of the epidemic, At the same time, the best efforts are still being made to track and control the outbreak. This approach may lead to a new outbreak, but it seems that the government is willing to take this risk. "

https://www.dw.com/zh/%E4%B8%AD%E5%9...%93/a-52912473
 
FluTrackers.com
@FluTrackers
?
12m
Back due popular demand -

Make Your Own Mask Weekend

A "last resort" as per CDC & "better than nothing" category.

Take your power back from this disease.

https://flutrackers.com/forum/forum/ideas-on-how-to-protect-yourself-from-new-coronavirus-2019-ncov/discussion-how-to-make-a-mask…

#coronavirus #COVID19


-------------------------------------


If your employer will not let you wear a homemade or other mask to work in a W.H.O. declared pandemic - file an OSHA complaint.

Here is the link for US workers:

https://osha.gov/workers/file_complaint.html…

Every country has a similar organization. Check yours.

#coronavirus #COVID19
 
My sister is a professional seamstress and she is making masks from old t-shirts for nursing home workers. Several organizations provide instructions for sanitizing the material and assembling a double-layered cotton mask that can be washed and reused.
 
Doctor shares useful tips for how to properly clean your groceries
COVID-19 PANDEMIC
by: Nexstar Media Wire

Posted: Mar 25, 2020 / 05:44 PM CDT / Updated: Mar 25, 2020 / 05:44 PM CDT

...
Once home, VanWingen recommends keeping your groceries outside your home, whether that be in the garage or car, for three days as he says coronavirus can live in the air for three hours and on plastic and metal surfaces for three days.

If you can’t wait, be ready to disinfect.

“Imagining that the groceries have some glitter on them, on the packaging and the bags,” VanWingen said when describing his surgical-like approach to disinfecting groceries. “Our goal is to not have any glitter at the end of this process in our house, on our hands, or more importantly on our face.”
...
https://wgntv.com/news/coronavirus/d...our-groceries/


Ok...this might seem a bit extreme but I am in several COVID-19 risk categories. I am not taking any packages inside the house since about 2 weeks. I am taking groceries to the garage where they can sit for 7 days. Of course, this means anything fresh or frozen is out. We are basically eating hurricane food. (Good thing that I love tuna! lol) See the paper posted at the top of the site "MUST READ" to understand how long COVID-19 might last on various surfaces. I am making our own bread for a lot of tuna sandwiches!
 
China to suspend entry of foreigners with visas, residence permits due to coronavirus

Reuters
March 26, 2020
11:31 AM EDT

BEIJING — China will temporarily suspend the entry of foreigners with valid Chinese visas and residence permits starting on March 28, as an interim measure in response to the coronavirus epidemic, the Foreign Ministry said on Thursday...:tiphat:
https://nationalpost.com/pmn/health-...to-coronavirus
 
A few things I've seen over the past few days that don't merit their own thread or post, but I'm putting here in case someone has seen any explanation of them:

- Multiple memes on the internet referencing a man co-infected with COVID-19 and Ebola, the most recent of which refer to the man having recovered. The only place on the planet that has reported an Ebola infection in humans in the last several months is the DRC, and they've only reported a couple cases in the past month as that outbreak is coming under control. A co-infection there seems unlikely. If the memes are just out of fear, why Ebola? MERS would be a much more likely threat as Ebola and COVID-19 are completely unrelated viruses. Where is this coming from?

- Multiple stories in the international media about a man dying of Hantavirus on a bus in China. Hantavirus is endemic in China (and the USA as well). Hantaviruses in China do not spread H2H. Why is this news? Yes, dying on a bus is an unusual place to die, but it seems unlikely to have gathered that much attention for the location alone. Is the suggestion that this is a misdiagnosed COVID-19 case? So what if it was? Is this being spread to target China as dirty and disease ridden?

- OSHA in the United States still hasn't modified its exceptions list to workplace illnesses that do not count as reportable accidents. There is an exception for (seasonal) flu so that if you contract the flu at work, your employer is not liable. Maybe there needs to be one for COVID-19? Otherwise, the resulting lawsuits might put businesses out of business very quickly.

- Most supermarkets around here have banned all returns, both to prevent potentially contaminated fomites from re-entering their store, as well as to discourage hoarding supplies with the presumption of returning them if they are not needed. What's going to happen in the event of a product recall (for reasons other than COVID-19)? Are people going to consume recalled product because they cannot return it? The stores will likely be liable in that case. I have deep concerns about botulism due to both home-canned food or consumed recalled food, as a botulism case would likely use up precious ventilator space for a much longer time than the average COVID-19 case. We really don't want this happening.
 
MARCH 26TH, 2020
Epidemiologist Behind Highly-Cited Coronavirus Model Admits He Was Wrong, Drastically Revises Model

By Amanda Prestigiacomo

Epidemiologist Neil Ferguson, who created the highly-cited Imperial College London coronavirus model, which has been cited by organizations like The New York Times and has been instrumental in governmental policy decision-making, offered a massive revision to his model on Wednesday.


Ferguson’s model projected 2.2 million dead people in the United States and 500,000 in the U.K. from COVID-19 if no action were taken to slow the virus and blunt its curve.
However, after just one day of ordered lockdowns in the U.K., Ferguson has changed his tune, revealing that far more people likely have the virus than his team figured. Now, the epidemiologist predicts, hospitals will be just fine taking on COVID-19 patients and estimates 20,000 or far fewer people will die from the virus itself from from its agitation of other ailments.
Ferguson thus dropped his prediction from 500,000 dead to 20,000.....

:tiphat:https://www.dailywire.com/news/epide...revises-model/
 
MARCH 26TH, 2020
Epidemiologist Behind Highly-Cited Coronavirus Model Admits He Was Wrong, Drastically Revises Model

By Amanda Prestigiacomo

Epidemiologist Neil Ferguson, who created the highly-cited Imperial College London coronavirus model, which has been cited by organizations like The New York Times and has been instrumental in governmental policy decision-making, offered a massive revision to his model on Wednesday.


Ferguson’s model projected 2.2 million dead people in the United States and 500,000 in the U.K. from COVID-19 if no action were taken to slow the virus and blunt its curve.
However, after just one day of ordered lockdowns in the U.K., Ferguson has changed his tune, revealing that far more people likely have the virus than his team figured. Now, the epidemiologist predicts, hospitals will be just fine taking on COVID-19 patients and estimates 20,000 or far fewer people will die from the virus itself from from its agitation of other ailments.
Ferguson thus dropped his prediction from 500,000 dead to 20,000.....

:tiphat:https://www.dailywire.com/news/epide...revises-model/

Here is the paper....I have a different read of it. Also Neil Ferguson has not tweeted since March 22. He has COVID-19. So who released this paper today? And why didn't he tweet about it?


COVID-19 reports


26 March 2020 - Imperial College London‌
Report 12: The Global Impact of COVID-19 and Strategies for Mitigation and Suppression

(Download Report 12)


Patrick GT Walker*, Charles Whittaker*, Oliver Watson, Marc Baguelin, Kylie E C Ainslie, Sangeeta Bhatia, Samir Bhatt, Adhiratha Boonyasiri, Olivia Boyd, Lorenzo Cattarino, Zulma Cucunub?, Gina Cuomo-Dannenburg, Amy Dighe, Christl A Donnelly, Ilaria Dorigatti, Sabine van Elsland, Rich FitzJohn, Seth Flaxman, Han Fu, Katy Gaythorpe, Lily Geidelberg, Nicholas Grassly, Will Green, Arran Hamlet, Katharina Hauck, David Haw, Sarah Hayes, Wes Hinsley, Natsuko Imai, David Jorgensen, Edward Knock, Daniel Laydon, Swapnil Mishra, Gemma Nedjati-Gilani, Lucy C Okell, Steven Riley, Hayley Thompson, Juliette Unwin, Robert Verity, Michaela Vollmer, Caroline Walters, Hao Wei Wang, Yuanrong Wang, Peter Winskill, Xiaoyue Xi, Neil M Ferguson[SUP]1[/SUP], Azra C Ghani[SUP]1[/SUP]

On behalf of the Imperial College COVID-19 Response Team

WHO Collaborating Centre for Infectious Disease Modelling
MRC Centre for Global Infectious Disease Analysis
Abdul Latif Jameel Institute for Disease and Emergency Analytics (J-IDEA)
Imperial College London

*Contributed equally, [SUP]1[/SUP]Correspondence: a.ghani@imperial.ac.uk; neil.ferguson@imperial.ac.uk

Summary Report 12
The world faces a severe and acute public health emergency due to the ongoing COVID-19 global pandemic. How individual countries respond in the coming weeks will be critical in influencing the trajectory of national epidemics. Here we combine data on age-specific contact patterns and COVID-19 severity to project the health impact of the pandemic in 202 countries. We compare predicted mortality impacts in the absence of interventions or spontaneous social distancing with what might be achieved with policies aimed at mitigating or suppressing transmission. Our estimates of mortality and healthcare demand are based on data from China and high-income countries; differences in underlying health conditions and healthcare system capacity will likely result in different patterns in low income settings.

We estimate that in the absence of interventions, COVID-19 would have resulted in 7.0 billion infections and 40 million deaths globally this year. Mitigation strategies focussing on shielding the elderly (60% reduction in social contacts) and slowing but not interrupting transmission (40% reduction in social contacts for wider population) could reduce this burden by half, saving 20 million lives, but we predict that even in this scenario, health systems in all countries will be quickly overwhelmed. This effect is likely to be most severe in lower income settings where capacity is lowest: our mitigated scenarios lead to peak demand for critical care beds in a typical low-income setting outstripping supply by a factor of 25, in contrast to a typical high-income setting where this factor is 7. As a result, we anticipate that the true burden in low income settings pursuing mitigation strategies could be substantially higher than reflected in these estimates.

Our analysis therefore suggests that healthcare demand can only be kept within manageable levels through the rapid adoption of public health measures (including testing and isolation of cases and wider social distancing measures) to suppress transmission, similar to those being adopted in many countries at the current time. If a suppression strategy is implemented early (at 0.2 deaths per 100,000 population per week) and sustained, then 38.7 million lives could be saved whilst if it is initiated when death numbers are higher (1.6 deaths per 100,000 population per week) then 30.7 million lives could be saved. Delays in implementing strategies to suppress transmission will lead to worse outcomes and fewer lives saved.

We do not consider the wider social and economic costs of suppression, which will be high and may be disproportionately so in lower income settings. Moreover, suppression strategies will need to be maintained in some manner until vaccines or effective treatments become available to avoid the risk of later epidemics. Our analysis highlights the challenging decisions faced by all governments in the coming weeks and months, but demonstrates the extent to which rapid, decisive and collective action now could save millions of lives.

Appendix data sources
Data on global unmitigated, mitigated and suppression scenarios: Imperial-College-COVID19-Global-unmitigated-mitigated-suppression-scenarios


https://www.imperial.ac.uk/mrc-globa...n-coronavirus/
 
neilferguson1.webp


neilferguson2.webp



neilferguson3.webp


neilferguson4.webp
 
Hattip Shiloh

Public Health Responses to COVID-19 Outbreaks on Cruise Ships — Worldwide, February–March 2020
...
SARS-CoV-2 RNA was identified on a variety of surfaces in cabins of both symptomatic and asymptomatic infected passengers up to 17 days after cabins were vacated on the Diamond Princess but before disinfection procedures had been conducted (Takuya Yamagishi, National Institute of Infectious Diseases, personal communication, 2020).
...
https://www.cdc.gov/mmwr/volumes/69/wr/mm6912e3.htm?s_cid=mm6912e3_w

https://flutrackers.com/forum/forum...-cruise-ships-—-worldwide-february–march-2020
 
Articles I have been reading are written in such a way as to suggest that the epidemiological model somehow has a material effect on the course of the pandemic. People don't seem to realize that a model simply uses data input by the user and projects outcomes based on the assumptions established within the model. If his first set of assumptions was wrong, the revised set could be just as wrong because the data haven't changed much. We still don't know the actual attack rates for various contact scenarios and certainly don't know the case fatality rate, and won't until after it's over.
 
I don't have any experience with epidemiological models, but I do have experience with groundwater transport modeling and all mathematical models share several things in common. All models are provided with input assumptions (things that can vary based on available data such as attack rate and CFR) and an initial set of conditions that typically don't vary (population). Many models are put through a calibration step where the model is set up to predict outcomes for a known scenario with a known outcome. The model variables are then adjusted so that the model results approximate the outcome of the known scenario. A simple example would be if we had data from a previous epidemic where the population, the number of deaths, and timeline are known. To calibrate the model if one wanted to use it to predict deaths over time, one would input the known parameters and then adjust the variables (attack rate and CFR) to match the observed deaths plotted versus time. Once this is achieved, one could then use those final variables (attack rate and CFR) to model a future scenario where the number of deaths and timeline are unknown.

Given the above, this statement from the cited paper troubles me,

"We estimate that in the absence of interventions, COVID-19 would have resulted in 7.0 billion infections and 40 million deaths globally this year."

This suggests that the modeled scenario for no intervention assumes a 100% attack rate and a case fatality rate of 0.571%, or 5.71 deaths per thousand. I'm not sure how Mr. Ferguson arrived at these assumptions, but they don't seem to match any of the data. Even the Diamond Princess didn't result in a 100% attack rate, but the case fatality rate based on the numbers available (712 cases and 11 deaths) would result in a CFR of 1.5% and not all cases have resolved. An additional death was added just yesterday. That one incident is probably the best data set available to date for understanding the effects of COVID-19 in a relatively controlled situation, albeit a scenario biased both in the manner and frequency of contacts and the average population age.

So, how did Mr. Ferguson calibrate his model and what input parameters changed so profoundly as to change his modeled outcome? I guess my point is that the model uses, and then changes, fundamentally uncertain parameters resulting in two very different conclusions on which policy will be decided. Was this motivated purely by science or were there other influences?
 
Based on population, it appears that Holland has been greatly impacted and it's still early in the outbreak for them. I fear it will get much worse for them.
 
https://flutrackers.com/forum/forum...ath-from-use-of-off-label-covid-19-treatments

https://www.taiwannews.com.tw/en/news/3876197
Exclusive: Chinese doctors say Wuhan coronavirus reinfection even deadlier
Instead of creating immunity the virus can reportedly reinfect an individual and hasten fatal heart attack
By Jules Quartly, Taiwan News, Contributing Writer
2020/02/14 15:0..
According to the message forwarded to Taiwan News, “It’s highly possible to get infected a second time. A few people recovered from the first time by their own immune system, but the meds they use are damaging their heart tissue, and when they get it the second time, the antibody doesn’t help but makes it worse, and they die a sudden death from heart failure.”...
 
Yes, this is something I have been watching closely, very closely. The potential for an ADE effect (antibody dependent enhancement). So far, all the literature, reports and evidence is unclear. If anyone sees anything that confirms this risk with sars-cov2, please post in the research section. This will be a devastating complication if true.
 
Actually, I will just share what studies I have seen up until now, here in one place, some of these are pre-print publications, some are discussion blogs.

Note: I don't know how to link multiple urls in a single post, so I'll add them as individual posts. That way at least you get the preview and a clickable link.
 
Understanding SARS-CoV-2-Mediated Inflammatory Responses: From Mechanisms to Potential Therapeutic Tools
 
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