tetano
Editor, Senior Moderator
Curr Opin Immunol. 2018 Apr 2;53:13-21. doi: 10.1016/j.coi.2018.03.019. [Epub ahead of print]
[h=1]Distinct and complementary roles of CD4 T cells in protective immunity to influenza virus.[/h] Sant AJ[SUP]1[/SUP], Richards KA[SUP]2[/SUP], Nayak J[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] CD4 T cells play a multiplicity of roles in protective immunity to influenza. Included in these functions are help for high affinity antibody production, enhancement of CD8 T cell expansion, function and memory, acceleration of the early innate response to infection and direct cytotoxicity. The influenza-specific CD4 T cell repertoire in humans established through exposures to infection and vaccination has been found to be highly variable in abundance, specificity and functionality. Deficits in particular subsets of CD4 T cells recruited into the response result in diminished antibody responses and protection from infection. Therefore, improved strategies for vaccination should include better methods to identify deficiencies in the circulating CD4 T cell repertoire, and vaccine constructs that increase the representation of CD4 T cells of the correct specificity and functionality.
PMID: 29621639 DOI: 10.1016/j.coi.2018.03.019
[h=1]Distinct and complementary roles of CD4 T cells in protective immunity to influenza virus.[/h] Sant AJ[SUP]1[/SUP], Richards KA[SUP]2[/SUP], Nayak J[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] CD4 T cells play a multiplicity of roles in protective immunity to influenza. Included in these functions are help for high affinity antibody production, enhancement of CD8 T cell expansion, function and memory, acceleration of the early innate response to infection and direct cytotoxicity. The influenza-specific CD4 T cell repertoire in humans established through exposures to infection and vaccination has been found to be highly variable in abundance, specificity and functionality. Deficits in particular subsets of CD4 T cells recruited into the response result in diminished antibody responses and protection from infection. Therefore, improved strategies for vaccination should include better methods to identify deficiencies in the circulating CD4 T cell repertoire, and vaccine constructs that increase the representation of CD4 T cells of the correct specificity and functionality.
PMID: 29621639 DOI: 10.1016/j.coi.2018.03.019