tetano
Editor, Senior Moderator
Immunity. 2014 Mar 12. pii: S1074-7613(14)00072-7. doi: 10.1016/j.immuni.2014.02.004. [Epub ahead of print]
Distinct Dendritic Cell Subsets Dictate the Fate Decision between Effector and Memory CD8+ T Cell Differentiation by a CD24-Dependent Mechanism.
Kim TS1, Gorski SA2, Hahn S3, Murphy KM4, Braciale TJ5.
Author information
Abstract
The contribution of different DC subsets to effector and memory CD8+ T cell generation during infection and the mechanism by which DCs controls these fate decisions is unclear. Here we demonstrated that the CD103+ and CD11bhi migratory respiratory DC (RDC) subsets after influenza virus infection activated naive virus-specific CD8+ T cells differentially. CD103+ RDCs supported the generation of CD8+ T effector (Teff) cells, which migrate from lymph nodes to the infected lungs. In contrast, migrant CD11bhi RDCs activated CD8+ T cells characteristic of central memory CD8+ T (CD8+ Tcm) cells including retention within the draining lymph nodes. CD103+ RDCs expressed CD24 at an elevated level, contributing to the propensity of this DC subpopulation to support CD8+ Teff cell differentiation. Mechanistically, CD24 was shown to regulate CD8+ T cell activation through HMGB1-mediated engagement of T cell RAGE. Thus, there is distribution of labor among DC subsets in regulating CD8+ T cell differentiation.
Copyright ? 2014 Elsevier Inc. All rights reserved.
PMID:
24631155
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24631155
Distinct Dendritic Cell Subsets Dictate the Fate Decision between Effector and Memory CD8+ T Cell Differentiation by a CD24-Dependent Mechanism.
Kim TS1, Gorski SA2, Hahn S3, Murphy KM4, Braciale TJ5.
Author information
Abstract
The contribution of different DC subsets to effector and memory CD8+ T cell generation during infection and the mechanism by which DCs controls these fate decisions is unclear. Here we demonstrated that the CD103+ and CD11bhi migratory respiratory DC (RDC) subsets after influenza virus infection activated naive virus-specific CD8+ T cells differentially. CD103+ RDCs supported the generation of CD8+ T effector (Teff) cells, which migrate from lymph nodes to the infected lungs. In contrast, migrant CD11bhi RDCs activated CD8+ T cells characteristic of central memory CD8+ T (CD8+ Tcm) cells including retention within the draining lymph nodes. CD103+ RDCs expressed CD24 at an elevated level, contributing to the propensity of this DC subpopulation to support CD8+ Teff cell differentiation. Mechanistically, CD24 was shown to regulate CD8+ T cell activation through HMGB1-mediated engagement of T cell RAGE. Thus, there is distribution of labor among DC subsets in regulating CD8+ T cell differentiation.
Copyright ? 2014 Elsevier Inc. All rights reserved.
PMID:
24631155
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24631155