tetano
Editor, Senior Moderator
Microb Pathog. 2016 Dec 27. pii: S0882-4010(16)30509-5. doi: 10.1016/j.micpath.2016.12.024. [Epub ahead of print]
[h=1]DNAzymes Dz13 target the c-jun possess antiviral activity against influenza A viruses.[/h] Zhang Z[SUP]1[/SUP], Zhang S[SUP]2[/SUP], Wang S[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The emergence of traditional anti-influenza A virus drug resistant strains highlights the need for more effective component. The earlier study demonstrated that c-jun which is a downstream molecule of JNK appears to have an important role in virus infections and inflammatory response. In the present study we explored the function of DNAzymes Dz13 that target the c-jun in the influenza A virus infected mice model. It was demonstrated that the BALB/c mice results in no toxic side effects after Dz13 treatment. And the infected mice displayed an enhanced survival after the Dz13 treatment compared to untreated mice. Simultaneously, the pulmonary inflammatory response and viral burden also decreased in the Dz13 treated mice. Furthermore, the proliferation of CD4[SUP]+[/SUP] and CD8[SUP]+[/SUP] T cells induced by virus infection was also impaired. The present data demonstrates an antiviral effect of Dz13 in vivo and the ability to reduce influenza virus induced inflammation, which suggest that Dz13 may be a potential therapeutic for influenza A virus infection.
Copyright ? 2016. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] Antiviral; C-jun; Dz13; Influenza A virus
PMID: 28039102 DOI: 10.1016/j.micpath.2016.12.024
[PubMed - as supplied by publisher]
[h=1]DNAzymes Dz13 target the c-jun possess antiviral activity against influenza A viruses.[/h] Zhang Z[SUP]1[/SUP], Zhang S[SUP]2[/SUP], Wang S[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The emergence of traditional anti-influenza A virus drug resistant strains highlights the need for more effective component. The earlier study demonstrated that c-jun which is a downstream molecule of JNK appears to have an important role in virus infections and inflammatory response. In the present study we explored the function of DNAzymes Dz13 that target the c-jun in the influenza A virus infected mice model. It was demonstrated that the BALB/c mice results in no toxic side effects after Dz13 treatment. And the infected mice displayed an enhanced survival after the Dz13 treatment compared to untreated mice. Simultaneously, the pulmonary inflammatory response and viral burden also decreased in the Dz13 treated mice. Furthermore, the proliferation of CD4[SUP]+[/SUP] and CD8[SUP]+[/SUP] T cells induced by virus infection was also impaired. The present data demonstrates an antiviral effect of Dz13 in vivo and the ability to reduce influenza virus induced inflammation, which suggest that Dz13 may be a potential therapeutic for influenza A virus infection.
Copyright ? 2016. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] Antiviral; C-jun; Dz13; Influenza A virus
PMID: 28039102 DOI: 10.1016/j.micpath.2016.12.024
[PubMed - as supplied by publisher]