tetano
Editor, Senior Moderator
J Infect Dis. 2019 Jan 31. doi: 10.1093/infdis/jiz044. [Epub ahead of print]
[h=1]Dynamic perspectives on the search for a universal influenza vaccine.[/h] Saad-Roy CM[SUP]1[/SUP], McDermott AB[SUP]2[/SUP], Grenfell BT[SUP]3,[/SUP][SUP]4,[/SUP][SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] A universal influenza vaccine (UIV) could considerably alleviate the public health burden of both seasonal and pandemic influenza. While significant progress has been achieved in clarifying basic immunology and virology relating to UIV, a number of important questions relating to the dynamics of infection, immunity, and pathogen evolution remain unsolved. Here, we review these gaps, which span integrative levels, from cellular to global and timescales from molecular events to decades. We argue that they can be best addressed by a tight integration of empirical (laboratory, epidemiological) research and theory and suggest fruitful areas for this synthesis. In particular, quantifying natural and vaccinal limitations on viral transmission are central to this effort.
PMID: 30715467 DOI: 10.1093/infdis/jiz044
[h=1]Dynamic perspectives on the search for a universal influenza vaccine.[/h] Saad-Roy CM[SUP]1[/SUP], McDermott AB[SUP]2[/SUP], Grenfell BT[SUP]3,[/SUP][SUP]4,[/SUP][SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] A universal influenza vaccine (UIV) could considerably alleviate the public health burden of both seasonal and pandemic influenza. While significant progress has been achieved in clarifying basic immunology and virology relating to UIV, a number of important questions relating to the dynamics of infection, immunity, and pathogen evolution remain unsolved. Here, we review these gaps, which span integrative levels, from cellular to global and timescales from molecular events to decades. We argue that they can be best addressed by a tight integration of empirical (laboratory, epidemiological) research and theory and suggest fruitful areas for this synthesis. In particular, quantifying natural and vaccinal limitations on viral transmission are central to this effort.
PMID: 30715467 DOI: 10.1093/infdis/jiz044