tetano
Editor, Senior Moderator
Ear Nose Throat J
. 2021 Jul 28;1455613211029783.
doi: 10.1177/01455613211029783. Online ahead of print.
Association Between Severity of COVID-19 Respiratory Disease and Risk of Obstructive Sleep Apnea
Giannicola Iannella[SUP] 1 [/SUP], Claudio Vicini[SUP] 1 2 [/SUP], Jerome R Lechien[SUP] 3 [/SUP], Claudia Ravaglia[SUP] 4 [/SUP], Venerino Poletti[SUP] 4 5 [/SUP], Simona di Cesare[SUP] 6 [/SUP], Elena Amicarelli[SUP] 6 [/SUP], Lucia Gardelli[SUP] 6 [/SUP], Carmela Grosso[SUP] 7 [/SUP], Aria Patacca[SUP] 7 [/SUP], Eleonora Magistrelli[SUP] 7 [/SUP], Michele De Benedetto[SUP] 8 [/SUP], Domenico Maurizio Toraldo[SUP] 9 [/SUP], Michele Arigliani[SUP] 8 [/SUP], Giovanni Cammaroto[SUP] 2 [/SUP], Giuseppe Meccariello[SUP] 2 [/SUP], Andrea De Vito[SUP] 10 [/SUP], Giuseppe Magliulo[SUP] 11 [/SUP], Antonio Greco[SUP] 11 [/SUP], Marco de Vincentiis[SUP] 11 [/SUP], Massimo Ralli[SUP] 11 [/SUP], Annalisa Pace[SUP] 11 [/SUP], Valentina Montincone[SUP] 12 [/SUP], Antonino Maniaci[SUP] 13 [/SUP], Salvatore Cocuzza[SUP] 13 [/SUP], Matteo Seligardi[SUP] 14 [/SUP], Ida di Giacinto[SUP] 15 [/SUP], Ruggero Massimo Corso[SUP] 16 [/SUP]
Affiliations
Abstract
Objectives: The purpose of this observational retrospective study was to evaluate, in patients with a severe acute respiratory syndrome coronavirus 2 infection, the association between the severity of coronavirus disease 2019 (COVID-19) respiratory illness and the risk of infected patients to develop obstructive sleep apnea (OSA).
Methods: Ninety-six patients with confirmed COVID-19 infection were enrolled in the study. The STOP-BANG questionnaire to investigate the risk of the OSA syndrome was filled in by the patients at admission. The enrolled patients were divided into 2 groups according to the respiratory disease: group 1 (72 patients), hospitalized patients undergoing conventional oxygen therapy; group 2 (24 patients), patients requiring enhanced respiratory support. STOP-BANG results of these 2 groups were compared to observe whether patients with high OSA risk more frequently presented a severe form of COVID-19.
Results: 41.6% of the patients in group 2 had a STOP-BANG score between 5 and 8 (high risk of having apnea); in contrast, 20.8% of the patients in group 1 had a STOP-BANG score between 5 and 8, with a statistically significant difference between the 2 groups (P = .05). A complementary trend was observed regarding the proportion of patients in the range 0 to 2, which classifies patients at a low risk of OSA (48.6% vs 20.8% for groups 1 and 2, P = .01).
Conclusions: According to our data, the chances of having a severe case of COVID-19 should be considered in patients at high risk of OSA.
Current knowledge/study rationale: Emerging research suggests that OSA could represent a potentially important risk factor for the severe forms of COVID-19. The purpose of this observational retrospective study was to evaluate the potential association between OSA and the severity of COVID-19 disease.
Study impact: According to our data, the likelihood of contracting a severe form of COVID-19 disease should be considered in patients at high risk of OSA.
Keywords: COVID-19; infection; obstructive sleep apnea; respiratory disease.
. 2021 Jul 28;1455613211029783.
doi: 10.1177/01455613211029783. Online ahead of print.
Association Between Severity of COVID-19 Respiratory Disease and Risk of Obstructive Sleep Apnea
Giannicola Iannella[SUP] 1 [/SUP], Claudio Vicini[SUP] 1 2 [/SUP], Jerome R Lechien[SUP] 3 [/SUP], Claudia Ravaglia[SUP] 4 [/SUP], Venerino Poletti[SUP] 4 5 [/SUP], Simona di Cesare[SUP] 6 [/SUP], Elena Amicarelli[SUP] 6 [/SUP], Lucia Gardelli[SUP] 6 [/SUP], Carmela Grosso[SUP] 7 [/SUP], Aria Patacca[SUP] 7 [/SUP], Eleonora Magistrelli[SUP] 7 [/SUP], Michele De Benedetto[SUP] 8 [/SUP], Domenico Maurizio Toraldo[SUP] 9 [/SUP], Michele Arigliani[SUP] 8 [/SUP], Giovanni Cammaroto[SUP] 2 [/SUP], Giuseppe Meccariello[SUP] 2 [/SUP], Andrea De Vito[SUP] 10 [/SUP], Giuseppe Magliulo[SUP] 11 [/SUP], Antonio Greco[SUP] 11 [/SUP], Marco de Vincentiis[SUP] 11 [/SUP], Massimo Ralli[SUP] 11 [/SUP], Annalisa Pace[SUP] 11 [/SUP], Valentina Montincone[SUP] 12 [/SUP], Antonino Maniaci[SUP] 13 [/SUP], Salvatore Cocuzza[SUP] 13 [/SUP], Matteo Seligardi[SUP] 14 [/SUP], Ida di Giacinto[SUP] 15 [/SUP], Ruggero Massimo Corso[SUP] 16 [/SUP]
Affiliations
- PMID: 34318690
- DOI: 10.1177/01455613211029783
Abstract
Objectives: The purpose of this observational retrospective study was to evaluate, in patients with a severe acute respiratory syndrome coronavirus 2 infection, the association between the severity of coronavirus disease 2019 (COVID-19) respiratory illness and the risk of infected patients to develop obstructive sleep apnea (OSA).
Methods: Ninety-six patients with confirmed COVID-19 infection were enrolled in the study. The STOP-BANG questionnaire to investigate the risk of the OSA syndrome was filled in by the patients at admission. The enrolled patients were divided into 2 groups according to the respiratory disease: group 1 (72 patients), hospitalized patients undergoing conventional oxygen therapy; group 2 (24 patients), patients requiring enhanced respiratory support. STOP-BANG results of these 2 groups were compared to observe whether patients with high OSA risk more frequently presented a severe form of COVID-19.
Results: 41.6% of the patients in group 2 had a STOP-BANG score between 5 and 8 (high risk of having apnea); in contrast, 20.8% of the patients in group 1 had a STOP-BANG score between 5 and 8, with a statistically significant difference between the 2 groups (P = .05). A complementary trend was observed regarding the proportion of patients in the range 0 to 2, which classifies patients at a low risk of OSA (48.6% vs 20.8% for groups 1 and 2, P = .01).
Conclusions: According to our data, the chances of having a severe case of COVID-19 should be considered in patients at high risk of OSA.
Current knowledge/study rationale: Emerging research suggests that OSA could represent a potentially important risk factor for the severe forms of COVID-19. The purpose of this observational retrospective study was to evaluate the potential association between OSA and the severity of COVID-19 disease.
Study impact: According to our data, the likelihood of contracting a severe form of COVID-19 disease should be considered in patients at high risk of OSA.
Keywords: COVID-19; infection; obstructive sleep apnea; respiratory disease.