tetano
Editor, Senior Moderator
Eat Weight Disord
. 2021 Jul 11.
doi: 10.1007/s40519-021-01269-3. Online ahead of print.
The negative impact of obesity on the occurrence and prognosis of the 2019 novel coronavirus (COVID-19) disease: a systematic review and meta-analysis
Tahereh Raeisi[SUP] 1 [/SUP], Hadis Mozaffari[SUP] 2 [/SUP], Nazaninzahra Sepehri[SUP] 3 [/SUP], Mina Darand[SUP] 4 [/SUP], Bahman Razi[SUP] 5 [/SUP], Nazila Garousi[SUP] 6 [/SUP], Mohammad Alizadeh[SUP] 7 [/SUP], Shahab Alizadeh[SUP] 8 [/SUP]
Affiliations
Abstract
Purpose: The 2019 novel coronavirus (COVID-19) is an emerging pandemic, with a disease course varying from asymptomatic infection to critical disease resulting to death. Recognition of prognostic factors is essential because of its growing prevalence and high clinical costs. This meta-analysis aimed to evaluate the global prevalence of obesity in COVID-19 patients and to investigate whether obesity is a risk factor for the COVID-19, COVID-19 severity, and its poor clinical outcomes including hospitalization, intensive care unit (ICU) admission, need for mechanical ventilation, and mortality.
Methods: The study protocol was registered in PROSPERO (CRD42020203386). A systematic search of Scopus, Medline, and Web of Sciences was conducted from 31 December 2019 to 1 June 2020 to find pertinent studies. After selection, 54 studies from 10 different countries were included in the quantitative analyses. Pooled odds ratios (OR) with 95% confidence intervals (CIs) were calculated to assess the associations.
Results: The prevalence of obesity was 33% (95% CI 30.0%-35.0%) among patients with COVID-19. Obesity was significantly associated with susceptibility to COVID-19 (OR = 2.42, 95% CI 1.58-3.70; moderate certainty) and COVID-19 severity (OR = 1.62, 95% CI 1.48-1.76; low certainty). Furthermore, obesity was a significant risk factor for hospitalization (OR = 1.75, 95% CI 1.47-2.09; very low certainty), mechanical ventilation (OR = 2.24, 95% CI 1.70-2.94; low certainty), intensive care unit (ICU) admission (OR = 1.75, 95% CI 1.38-2.22; low certainty), and death (OR = 1.23, 95% CI 1.06-1.41; low certainty) in COVID-19 patients. In the subgroup analyses, these associations were supported by the majority of subgroups.
Conclusion: Obesity is associated with COVID-19, need for hospitalization, mechanical ventilation, ICU admission, and death due to COVID-19.
Level of evidence: Level I, systematic reviews and meta-analyses.
Keywords: COVID-19; Death; Hospitalization; Intensive care unit; Mechanical ventilation; Obesity.
. 2021 Jul 11.
doi: 10.1007/s40519-021-01269-3. Online ahead of print.
The negative impact of obesity on the occurrence and prognosis of the 2019 novel coronavirus (COVID-19) disease: a systematic review and meta-analysis
Tahereh Raeisi[SUP] 1 [/SUP], Hadis Mozaffari[SUP] 2 [/SUP], Nazaninzahra Sepehri[SUP] 3 [/SUP], Mina Darand[SUP] 4 [/SUP], Bahman Razi[SUP] 5 [/SUP], Nazila Garousi[SUP] 6 [/SUP], Mohammad Alizadeh[SUP] 7 [/SUP], Shahab Alizadeh[SUP] 8 [/SUP]
Affiliations
- PMID: 34247342
- DOI: 10.1007/s40519-021-01269-3
Abstract
Purpose: The 2019 novel coronavirus (COVID-19) is an emerging pandemic, with a disease course varying from asymptomatic infection to critical disease resulting to death. Recognition of prognostic factors is essential because of its growing prevalence and high clinical costs. This meta-analysis aimed to evaluate the global prevalence of obesity in COVID-19 patients and to investigate whether obesity is a risk factor for the COVID-19, COVID-19 severity, and its poor clinical outcomes including hospitalization, intensive care unit (ICU) admission, need for mechanical ventilation, and mortality.
Methods: The study protocol was registered in PROSPERO (CRD42020203386). A systematic search of Scopus, Medline, and Web of Sciences was conducted from 31 December 2019 to 1 June 2020 to find pertinent studies. After selection, 54 studies from 10 different countries were included in the quantitative analyses. Pooled odds ratios (OR) with 95% confidence intervals (CIs) were calculated to assess the associations.
Results: The prevalence of obesity was 33% (95% CI 30.0%-35.0%) among patients with COVID-19. Obesity was significantly associated with susceptibility to COVID-19 (OR = 2.42, 95% CI 1.58-3.70; moderate certainty) and COVID-19 severity (OR = 1.62, 95% CI 1.48-1.76; low certainty). Furthermore, obesity was a significant risk factor for hospitalization (OR = 1.75, 95% CI 1.47-2.09; very low certainty), mechanical ventilation (OR = 2.24, 95% CI 1.70-2.94; low certainty), intensive care unit (ICU) admission (OR = 1.75, 95% CI 1.38-2.22; low certainty), and death (OR = 1.23, 95% CI 1.06-1.41; low certainty) in COVID-19 patients. In the subgroup analyses, these associations were supported by the majority of subgroups.
Conclusion: Obesity is associated with COVID-19, need for hospitalization, mechanical ventilation, ICU admission, and death due to COVID-19.
Level of evidence: Level I, systematic reviews and meta-analyses.
Keywords: COVID-19; Death; Hospitalization; Intensive care unit; Mechanical ventilation; Obesity.