tetano
Editor, Senior Moderator
Poult Sci. 2012 Oct;91(10):2517-22.
Effect of intranasal administration of Lactobacillus fermentum CJL-112 on horizontal transmission of influenza virus in chickens.
Youn HN, Lee YN, Lee DH, Park JK, Yuk SS, Lee HJ, Yeo JM, Yang SY, Lee JB, Park SY, Choi IS, Song CS.
Source
Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, 143-701, Korea; and.
Abstract
The aim of this study was to determine whether intranasal administration of Lactobacillus sp. could prevent horizontal transmission of H9N2 avian influenza virus (AIV) in specific-pathogen-free chickens. Three-week-old chickens received 500 μL of 1.5 ? 10(9) cfu of Lactobacillus fermentum CJL-112 strain (CJL) intranasally for 7 d before and 14 d after a challenge. Challenged chickens, each inoculated with H9N2 AIV, were kept in either direct or indirect contact with naive chickens, and morbidity and viral shedding were monitored. We demonstrated that the intranasal administration of CJL significantly decreased the number of chickens with viral shedding from the gastrointestinal tract in the indirect contact chickens (P < 0.001) and also significantly reduced viral shedding from the respiratory tract in the challenged (P < 0.05) and the direct contact chickens (P < 0.001) than those in the control group. Hence, the use of this lactobacilli strain may constitute a novel and effectively plausible alternative to prevent and control H9N2 AIV infection in chickens.
PMID:
22991537
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/22991537
Effect of intranasal administration of Lactobacillus fermentum CJL-112 on horizontal transmission of influenza virus in chickens.
Youn HN, Lee YN, Lee DH, Park JK, Yuk SS, Lee HJ, Yeo JM, Yang SY, Lee JB, Park SY, Choi IS, Song CS.
Source
Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, 143-701, Korea; and.
Abstract
The aim of this study was to determine whether intranasal administration of Lactobacillus sp. could prevent horizontal transmission of H9N2 avian influenza virus (AIV) in specific-pathogen-free chickens. Three-week-old chickens received 500 μL of 1.5 ? 10(9) cfu of Lactobacillus fermentum CJL-112 strain (CJL) intranasally for 7 d before and 14 d after a challenge. Challenged chickens, each inoculated with H9N2 AIV, were kept in either direct or indirect contact with naive chickens, and morbidity and viral shedding were monitored. We demonstrated that the intranasal administration of CJL significantly decreased the number of chickens with viral shedding from the gastrointestinal tract in the indirect contact chickens (P < 0.001) and also significantly reduced viral shedding from the respiratory tract in the challenged (P < 0.05) and the direct contact chickens (P < 0.001) than those in the control group. Hence, the use of this lactobacilli strain may constitute a novel and effectively plausible alternative to prevent and control H9N2 AIV infection in chickens.
PMID:
22991537
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/22991537