tetano
Editor, Senior Moderator
Expert Rev Vaccines. 2018 Jun 30. doi: 10.1080/14760584.2018.1495077. [Epub ahead of print]
[h=1]Effectiveness and safety of dual influenza and pneumococcal vaccination versus separate administration or no vaccination in older adults: A meta-analysis.[/h] Yin M[SUP]1[/SUP], Huang L[SUP]1[/SUP], Zhang Y[SUP]1[/SUP], Yu N[SUP]2[/SUP], Xu X[SUP]1[/SUP], Liang Y[SUP]1[/SUP], Ni J[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Available influenza vaccine is insufficient to prevent influenza-related complications in older adults and dual pneumococcal and influenza vaccination is recommended for adults aged ≥65 years. However, the advantages of dual pneumococcal and influenza vaccination have not been clarified and controversy remains regarding their optimal use. Areas covered: This meta-analysis was conducted on 25 January 2018 using PubMed, the Cochrane Library, and Embase databases. Seventeen studies were selected ultimately for meta-analysis using a multi-step approach by two separate authors. Primary outcomes were pneumonia, pneumococcal pneumonia, influenza, hospitalization, and all-cause mortality rates, and the secondary outcome was adverse effects (AEs). Expert commentary: Simultaneous influenza and pneumococcal vaccination is superior to separate vaccine administration or to no vaccination among older adults. Given either, influenza vaccines have a greater protective effect than pneumococcal vaccines. Both vaccines showed acceptable safety profiles and AEs were mild or moderate. Overall, our findings highlight the importance of concomitant influenza and pneumococcal vaccination and dual vaccines should be frequently recommended in older adults in practice.
[h=4]KEYWORDS:[/h] Effectiveness; elderly; influenza vaccination; pneumococcal vaccination; safety
PMID: 29961353 DOI: 10.1080/14760584.2018.1495077
[h=1]Effectiveness and safety of dual influenza and pneumococcal vaccination versus separate administration or no vaccination in older adults: A meta-analysis.[/h] Yin M[SUP]1[/SUP], Huang L[SUP]1[/SUP], Zhang Y[SUP]1[/SUP], Yu N[SUP]2[/SUP], Xu X[SUP]1[/SUP], Liang Y[SUP]1[/SUP], Ni J[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Available influenza vaccine is insufficient to prevent influenza-related complications in older adults and dual pneumococcal and influenza vaccination is recommended for adults aged ≥65 years. However, the advantages of dual pneumococcal and influenza vaccination have not been clarified and controversy remains regarding their optimal use. Areas covered: This meta-analysis was conducted on 25 January 2018 using PubMed, the Cochrane Library, and Embase databases. Seventeen studies were selected ultimately for meta-analysis using a multi-step approach by two separate authors. Primary outcomes were pneumonia, pneumococcal pneumonia, influenza, hospitalization, and all-cause mortality rates, and the secondary outcome was adverse effects (AEs). Expert commentary: Simultaneous influenza and pneumococcal vaccination is superior to separate vaccine administration or to no vaccination among older adults. Given either, influenza vaccines have a greater protective effect than pneumococcal vaccines. Both vaccines showed acceptable safety profiles and AEs were mild or moderate. Overall, our findings highlight the importance of concomitant influenza and pneumococcal vaccination and dual vaccines should be frequently recommended in older adults in practice.
[h=4]KEYWORDS:[/h] Effectiveness; elderly; influenza vaccination; pneumococcal vaccination; safety
PMID: 29961353 DOI: 10.1080/14760584.2018.1495077