tetano
Editor, Senior Moderator
Clin Vaccine Immunol. 2014 Dec 24. pii: CVI.00673-14. [Epub ahead of print]
[h=1]Effectiveness of influenza and pneumococcal vaccines in preventing pneumonia development and hospitalization: a prospective cohort study.[/h] Song JY[SUP]1[/SUP], Lee JS[SUP]2[/SUP], Wie S[SUP]3[/SUP], Kim HY[SUP]4[/SUP], Lee J[SUP]5[/SUP], Seo YB[SUP]5[/SUP], Jeong HW[SUP]6[/SUP], Kim SW[SUP]7[/SUP], Lee SH[SUP]8[/SUP], Park K[SUP]9[/SUP], Noh JY[SUP]1[/SUP], Choi WS[SUP]1[/SUP], Cheong HJ[SUP]1[/SUP], Kim WJ[SUP]10[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Pneumonia and acute exacerbation of chronic illness are leading causes of influenza-related hospitalization. Therefore, influenza and pneumococcal vaccinations are strongly recommended for adults with comorbidities. Using a hospital-based influenza surveillance system, we performed a multicenter, prospective cohort study of patients visiting emergency rooms with influenza-like illness (ILI) during the influenza epidemic period in 2013-2014. Patients aged ≥ 19 years were enrolled, and clinical data was collected. Multivariate analyses were performed to estimate the effectiveness of influenza and pneumococcal vaccination in preventing pneumonia development and hospitalization. During study periods, 2,262 patients with ILI were registered. Among 2,217 patients with available vaccination records, 31.9% (707 patients) and 9.7% (216 patients) had received influenza and pneumococcal vaccines, respectively. Among patients who had been administered a pneumococcal vaccine, 94.4% had received the 23-valent polysaccharide vaccine (PPV23). The adjusted influenza vaccine effectiveness for preventing pneumonia development and hospitalization was 64.0% (95% confidence interval [CI] = 29% - 81%) and 35.0% (95% CI = 12% - 52%), respectively. Pneumococcal vaccination did not reduce pneumonia development or hospitalization. In conclusion, influenza rather than PPV23 vaccination may reduce pneumonia development and hospitalization in patients with preceding ILI.
Copyright ? 2014, American Society for Microbiology. All Rights Reserved.
PMID: 25540271 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25540271
[h=1]Effectiveness of influenza and pneumococcal vaccines in preventing pneumonia development and hospitalization: a prospective cohort study.[/h] Song JY[SUP]1[/SUP], Lee JS[SUP]2[/SUP], Wie S[SUP]3[/SUP], Kim HY[SUP]4[/SUP], Lee J[SUP]5[/SUP], Seo YB[SUP]5[/SUP], Jeong HW[SUP]6[/SUP], Kim SW[SUP]7[/SUP], Lee SH[SUP]8[/SUP], Park K[SUP]9[/SUP], Noh JY[SUP]1[/SUP], Choi WS[SUP]1[/SUP], Cheong HJ[SUP]1[/SUP], Kim WJ[SUP]10[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Pneumonia and acute exacerbation of chronic illness are leading causes of influenza-related hospitalization. Therefore, influenza and pneumococcal vaccinations are strongly recommended for adults with comorbidities. Using a hospital-based influenza surveillance system, we performed a multicenter, prospective cohort study of patients visiting emergency rooms with influenza-like illness (ILI) during the influenza epidemic period in 2013-2014. Patients aged ≥ 19 years were enrolled, and clinical data was collected. Multivariate analyses were performed to estimate the effectiveness of influenza and pneumococcal vaccination in preventing pneumonia development and hospitalization. During study periods, 2,262 patients with ILI were registered. Among 2,217 patients with available vaccination records, 31.9% (707 patients) and 9.7% (216 patients) had received influenza and pneumococcal vaccines, respectively. Among patients who had been administered a pneumococcal vaccine, 94.4% had received the 23-valent polysaccharide vaccine (PPV23). The adjusted influenza vaccine effectiveness for preventing pneumonia development and hospitalization was 64.0% (95% confidence interval [CI] = 29% - 81%) and 35.0% (95% CI = 12% - 52%), respectively. Pneumococcal vaccination did not reduce pneumonia development or hospitalization. In conclusion, influenza rather than PPV23 vaccination may reduce pneumonia development and hospitalization in patients with preceding ILI.
Copyright ? 2014, American Society for Microbiology. All Rights Reserved.
PMID: 25540271 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25540271