tetano
Editor, Senior Moderator
Pediatr Int. 2015 Dec 15. doi: 10.1111/ped.12888. [Epub ahead of print]
[h=1]Effectiveness of maternal influenza immunization in young infants in Japan.[/h] Sugimura T[SUP]1[/SUP], Nagai T[SUP]2[/SUP], Kobayashi H[SUP]3[/SUP], Ozaki Y[SUP]4[/SUP], Yamakawa R[SUP]4[/SUP], Hirata R[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Infants with influenza, particularly those younger than one year of age, are at high risk of developing a severe case or dying. Recently, owing to the spread of pandemic influenza A (H1N1) 2009, the Advisory Committee on Immunization Practices recommended maternal immunization to reduce the risk of influenza infection in pregnant women and infants. Such reporting is rare in Japan.
[h=4]AIM:[/h] We investigated the effect on the newborn of influenza vaccination of pregnant women in Japan.
[h=4]METHODS:[/h] The study included 200 infants who were born to healthy mothers at Kobayashi Ladies Clinic during influenza season from November 2010 to April 2011. The incidence of fever and laboratory confirmed influenza was assessed in the infants for the six months after their birth.
[h=4]RESULTS:[/h] Of the 200 infants, 4 were excluded from this study because it became difficult to follow them. The 106 infants in the group whose mothers received the influenza vaccine (vaccinated group) before parturition were compared with the 90 infants in the group whose mothers did not receive the influenza vaccine (non-vaccinated group). Fever was noted in 36 infants (34.0%) in the vaccinated group and 47 infants (52.2%) in the non-vaccinated group (p < 0.007), and the incidences of influenza were 0 (0%) and 5 (5.6%), respectively (p = 0.019). The incidence of fever and influenza among infants was significantly lower in the vaccinated group compared with the non-vaccinated group.
[h=4]CONCLUSION:[/h] Maternal influenza immunization should be actively recommended in Japan to protect their newborn children from influenza viruses. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] infant; influenza; maternal vaccination; pandemic influenza
PMID: 26670462 [PubMed - as supplied by publisher]
[h=1]Effectiveness of maternal influenza immunization in young infants in Japan.[/h] Sugimura T[SUP]1[/SUP], Nagai T[SUP]2[/SUP], Kobayashi H[SUP]3[/SUP], Ozaki Y[SUP]4[/SUP], Yamakawa R[SUP]4[/SUP], Hirata R[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Infants with influenza, particularly those younger than one year of age, are at high risk of developing a severe case or dying. Recently, owing to the spread of pandemic influenza A (H1N1) 2009, the Advisory Committee on Immunization Practices recommended maternal immunization to reduce the risk of influenza infection in pregnant women and infants. Such reporting is rare in Japan.
[h=4]AIM:[/h] We investigated the effect on the newborn of influenza vaccination of pregnant women in Japan.
[h=4]METHODS:[/h] The study included 200 infants who were born to healthy mothers at Kobayashi Ladies Clinic during influenza season from November 2010 to April 2011. The incidence of fever and laboratory confirmed influenza was assessed in the infants for the six months after their birth.
[h=4]RESULTS:[/h] Of the 200 infants, 4 were excluded from this study because it became difficult to follow them. The 106 infants in the group whose mothers received the influenza vaccine (vaccinated group) before parturition were compared with the 90 infants in the group whose mothers did not receive the influenza vaccine (non-vaccinated group). Fever was noted in 36 infants (34.0%) in the vaccinated group and 47 infants (52.2%) in the non-vaccinated group (p < 0.007), and the incidences of influenza were 0 (0%) and 5 (5.6%), respectively (p = 0.019). The incidence of fever and influenza among infants was significantly lower in the vaccinated group compared with the non-vaccinated group.
[h=4]CONCLUSION:[/h] Maternal influenza immunization should be actively recommended in Japan to protect their newborn children from influenza viruses. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] infant; influenza; maternal vaccination; pandemic influenza
PMID: 26670462 [PubMed - as supplied by publisher]