tetano
Editor, Senior Moderator
J Infect Dis. 2012 May 2. [Epub ahead of print]
Effectiveness of One Dose of 2009 Influenza A (H1N1) Vaccine at Preventing Hospitalization with Pandemic H1N1 Influenza in Children 7 Months to 9 Years of Age.
Hadler JL, Baker TN, Papadouka V, France AM, Zimmerman C, Livingston KA, Zucker JR.
Source
New York City Department of Health and Mental Hygiene, New York, New York.
Abstract
The availability of a well established immunization registry to provide vaccination information, a school-located vaccination campaign followed by continued 2009 influenza A (H1N1) (pH1N1) activity, and a requirement to report hospitalized influenza cases provided an opportunity to estimate vaccine effectiveness (VE) of an initial dose of pH1N1 monovalent vaccine in children 7 months to 9 years old. Seventy-eight case-children and 729 date-of-birth and zipcode matched controls were studied. VE of a single vaccine dose in preventing pH1N1 hospitalization ≥14 days after vaccination was 82% (95% CI, 0-100%, p=0.04) in children 3-9 years, but zero (-3%, 95% CI, <0-75%) in children 7-35 months. These findings are consistent with those from prelicensure immunogenicity studies and have implications for interpretation of immunogenicity studies and setting priorities for vaccination of young children in future pandemics. Immunization registries can provide a simple, rapid assessment of VE to evaluate and inform vaccination policy.
PMID:
22551808
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22551808
Effectiveness of One Dose of 2009 Influenza A (H1N1) Vaccine at Preventing Hospitalization with Pandemic H1N1 Influenza in Children 7 Months to 9 Years of Age.
Hadler JL, Baker TN, Papadouka V, France AM, Zimmerman C, Livingston KA, Zucker JR.
Source
New York City Department of Health and Mental Hygiene, New York, New York.
Abstract
The availability of a well established immunization registry to provide vaccination information, a school-located vaccination campaign followed by continued 2009 influenza A (H1N1) (pH1N1) activity, and a requirement to report hospitalized influenza cases provided an opportunity to estimate vaccine effectiveness (VE) of an initial dose of pH1N1 monovalent vaccine in children 7 months to 9 years old. Seventy-eight case-children and 729 date-of-birth and zipcode matched controls were studied. VE of a single vaccine dose in preventing pH1N1 hospitalization ≥14 days after vaccination was 82% (95% CI, 0-100%, p=0.04) in children 3-9 years, but zero (-3%, 95% CI, <0-75%) in children 7-35 months. These findings are consistent with those from prelicensure immunogenicity studies and have implications for interpretation of immunogenicity studies and setting priorities for vaccination of young children in future pandemics. Immunization registries can provide a simple, rapid assessment of VE to evaluate and inform vaccination policy.
PMID:
22551808
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22551808