tetano
Editor, Senior Moderator
Vaccine. 2010 Sep 24. [Epub ahead of print]
Effectiveness of seasonal 2008-2009, 2009-2010 and pandemic vaccines, to prevent influenza hospitalizations during the autumn 2009 influenza pandemic wave in Castell?n, Spain. A test-negative, hospital-based, case-control study.
Puig-Barber? J, Arnedo-Pena A, Pardo-Serrano F, Tirado-Balaguer MD, P?rez-Vilar S, Silvestre-Silvestre E, Calvo-Mas C, Safont-Adsuara L, Ruiz-Garc?a M; The Members of the Surveillance and Vaccine Evaluation Group during the autumn 2009 H1N1 pandemic wave in Castell?n, Spain.
Health Promotion Unit, Centro de Salud P?blica, Avda del Mar, 12, 12003 Castell?n, Spain; Vaccines Research, Centre for Public Health Research (CSISP), Valencia, Spain.
Abstract
We estimate the impact of the two previous influenza seasonal vaccines and the pandemic vaccine on risk of A (H1N1) 2009 laboratory confirmed hospitalizations during the autumn 2009 pandemic wave in Castell?n, Spain. We conducted a test-negative, hospital-based, case-control study. Influenza A (H1N1) 2009 infection was detected in 147 (44%) of 334 patients hospitalized for a presumptive influenza related illness. No effect was observed for the 2008-2009 and 2009-2010 seasonal influenza vaccines. However, the pandemic vaccine was associated with an adjusted vaccine effectiveness of 90% (95% CI, 48-100%). Pandemic vaccines were effective in preventing pandemic influenza associated hospitalizations.
PMID: 20875486 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20875486
Effectiveness of seasonal 2008-2009, 2009-2010 and pandemic vaccines, to prevent influenza hospitalizations during the autumn 2009 influenza pandemic wave in Castell?n, Spain. A test-negative, hospital-based, case-control study.
Puig-Barber? J, Arnedo-Pena A, Pardo-Serrano F, Tirado-Balaguer MD, P?rez-Vilar S, Silvestre-Silvestre E, Calvo-Mas C, Safont-Adsuara L, Ruiz-Garc?a M; The Members of the Surveillance and Vaccine Evaluation Group during the autumn 2009 H1N1 pandemic wave in Castell?n, Spain.
Health Promotion Unit, Centro de Salud P?blica, Avda del Mar, 12, 12003 Castell?n, Spain; Vaccines Research, Centre for Public Health Research (CSISP), Valencia, Spain.
Abstract
We estimate the impact of the two previous influenza seasonal vaccines and the pandemic vaccine on risk of A (H1N1) 2009 laboratory confirmed hospitalizations during the autumn 2009 pandemic wave in Castell?n, Spain. We conducted a test-negative, hospital-based, case-control study. Influenza A (H1N1) 2009 infection was detected in 147 (44%) of 334 patients hospitalized for a presumptive influenza related illness. No effect was observed for the 2008-2009 and 2009-2010 seasonal influenza vaccines. However, the pandemic vaccine was associated with an adjusted vaccine effectiveness of 90% (95% CI, 48-100%). Pandemic vaccines were effective in preventing pandemic influenza associated hospitalizations.
PMID: 20875486 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20875486