tetano
Editor, Senior Moderator
J Microbiol Immunol Infect. 2019 Oct 29. pii: S1684-1182(19)30166-5. doi: 10.1016/j.jmii.2019.09.010. [Epub ahead of print] [h=1]Effects of influenza vaccine and sun exposure time against laboratory-confirmed influenza hospitalizations among young children during the 2012-13 to 2015-16 influenza seasons.[/h]
Wang CY[SUP]1[/SUP], Chang YH[SUP]2[/SUP], Huang LM[SUP]2[/SUP], Chi H[SUP]3[/SUP], Chiu NC[SUP]3[/SUP], Chang LY[SUP]2[/SUP], Lu CY[SUP]2[/SUP], Huang YC[SUP]4[/SUP], Lin HC[SUP]5[/SUP], Lee JT[SUP]6[/SUP], Liu CC[SUP]7[/SUP], Huang YC[SUP]8[/SUP], Ho YH[SUP]9[/SUP], Tu YH[SUP]10[/SUP], Wang JY[SUP]11[/SUP], Huang DT[SUP]12[/SUP]; Taiwan Pediatric Infectious Disease Alliance.
[h=3]Author information[/h] 1 Department of Pediatric Infectious Diseases, MacKay Children's Hospital, Taipei, Taiwan; Department of Pediatrics, Taipei Medical University Hospital, Taipei, Taiwan. 2 Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan. 3 Department of Pediatric Infectious Diseases, MacKay Children's Hospital, Taipei, Taiwan; Department of Medicine, Mackay Medical College, New Taipei City, Taiwan; MacKay Junior College of Medicine, Nursing and Management, Taipei, Taiwan. 4 Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan. 5 Department of Pediatric Infectious Diseases, China Medical University Children's Hospital, Taichung, Taiwan. 6 Department of Pediatrics, National Taiwan University Hospital, Yun-Lin Branch, Yunlin, Taiwan. 7 Department of Pediatrics, National Cheng Kung University Hospital, Tainan, Taiwan. 8 Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan. 9 Division of Infectious Disease, Department of Medicine, Buddhist Tzu Chi General Hospital, Hualien, Taiwan. 10 Department of Statistics, National Cheng Kung University, Tainan, Taiwan. 11 Department of Pediatric Infectious Diseases, MacKay Children's Hospital, Taipei, Taiwan. 12 Department of Pediatric Infectious Diseases, MacKay Children's Hospital, Taipei, Taiwan; Department of Medicine, Mackay Medical College, New Taipei City, Taiwan. Electronic address: zoning12huang@gmail.com.
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Influenza is a major cause of acute respiratory infection burden worldwide, leading to many hospitalizations. An annual influenza vaccine is believed to be the best way to prevent influenza-related illnesses. We focused on the efficacies of other possible preventive measures such as increasing sun exposure time and dietary supplements to prevent these illnesses.
[h=4]METHODS:[/h] We conducted a matched-pair case-control study along with the Taiwan Pediatric Infectious Disease Alliance. We included influenza-related hospitalized patients with age ranging from 6 months to 5 years during the 2012-2013, 2013-2014, 2014-2015, and 2015-2016 influenza seasons. The controls were comparable to cases in age, sex, and residential area and had no influenza-related hospitalization records in the same season. We extracted data from vaccination histories and got the patients' guardians to complete questionnaires. Data were analyzed using conditional logistic regression.
[h=4]RESULTS:[/h] We enrolled 1514 children (421 influenza-infected cases and 1093 controls) in the study. We found seasonal influenza vaccination to be an independent protective factor against hospitalizations owing to influenza [p < 0.01; odds ratio (OR), 0.427; 95% confidence interval (CI), 0.306-0.594]. Children with mean sun exposure time of >7 h/week had a significantly lower risk of influenza-related hospitalizations than those with the mean sun exposure time of ≤7 h/week (p < 0.05; OR, 0.667; 95% CI, 0.491-0.906).
[h=4]CONCLUSIONS:[/h] Seasonal influenza vaccination effectively prevents influenza-related hospitalizations in children aged ≤5 years. Besides, >7 h of sun exposure/week may also be associated with lower risk of influenza-related hospitalizations in children.
Copyright ? 2019. Published by Elsevier B.V.
[h=4]KEYWORDS:[/h] Hospitalization; Influenza; Sun exposure time; Vaccine effectiveness
PMID: 31732418 DOI: 10.1016/j.jmii.2019.09.010
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Wang CY[SUP]1[/SUP], Chang YH[SUP]2[/SUP], Huang LM[SUP]2[/SUP], Chi H[SUP]3[/SUP], Chiu NC[SUP]3[/SUP], Chang LY[SUP]2[/SUP], Lu CY[SUP]2[/SUP], Huang YC[SUP]4[/SUP], Lin HC[SUP]5[/SUP], Lee JT[SUP]6[/SUP], Liu CC[SUP]7[/SUP], Huang YC[SUP]8[/SUP], Ho YH[SUP]9[/SUP], Tu YH[SUP]10[/SUP], Wang JY[SUP]11[/SUP], Huang DT[SUP]12[/SUP]; Taiwan Pediatric Infectious Disease Alliance.
[h=3]Author information[/h] 1 Department of Pediatric Infectious Diseases, MacKay Children's Hospital, Taipei, Taiwan; Department of Pediatrics, Taipei Medical University Hospital, Taipei, Taiwan. 2 Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan. 3 Department of Pediatric Infectious Diseases, MacKay Children's Hospital, Taipei, Taiwan; Department of Medicine, Mackay Medical College, New Taipei City, Taiwan; MacKay Junior College of Medicine, Nursing and Management, Taipei, Taiwan. 4 Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan. 5 Department of Pediatric Infectious Diseases, China Medical University Children's Hospital, Taichung, Taiwan. 6 Department of Pediatrics, National Taiwan University Hospital, Yun-Lin Branch, Yunlin, Taiwan. 7 Department of Pediatrics, National Cheng Kung University Hospital, Tainan, Taiwan. 8 Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan. 9 Division of Infectious Disease, Department of Medicine, Buddhist Tzu Chi General Hospital, Hualien, Taiwan. 10 Department of Statistics, National Cheng Kung University, Tainan, Taiwan. 11 Department of Pediatric Infectious Diseases, MacKay Children's Hospital, Taipei, Taiwan. 12 Department of Pediatric Infectious Diseases, MacKay Children's Hospital, Taipei, Taiwan; Department of Medicine, Mackay Medical College, New Taipei City, Taiwan. Electronic address: zoning12huang@gmail.com.
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Influenza is a major cause of acute respiratory infection burden worldwide, leading to many hospitalizations. An annual influenza vaccine is believed to be the best way to prevent influenza-related illnesses. We focused on the efficacies of other possible preventive measures such as increasing sun exposure time and dietary supplements to prevent these illnesses.
[h=4]METHODS:[/h] We conducted a matched-pair case-control study along with the Taiwan Pediatric Infectious Disease Alliance. We included influenza-related hospitalized patients with age ranging from 6 months to 5 years during the 2012-2013, 2013-2014, 2014-2015, and 2015-2016 influenza seasons. The controls were comparable to cases in age, sex, and residential area and had no influenza-related hospitalization records in the same season. We extracted data from vaccination histories and got the patients' guardians to complete questionnaires. Data were analyzed using conditional logistic regression.
[h=4]RESULTS:[/h] We enrolled 1514 children (421 influenza-infected cases and 1093 controls) in the study. We found seasonal influenza vaccination to be an independent protective factor against hospitalizations owing to influenza [p < 0.01; odds ratio (OR), 0.427; 95% confidence interval (CI), 0.306-0.594]. Children with mean sun exposure time of >7 h/week had a significantly lower risk of influenza-related hospitalizations than those with the mean sun exposure time of ≤7 h/week (p < 0.05; OR, 0.667; 95% CI, 0.491-0.906).
[h=4]CONCLUSIONS:[/h] Seasonal influenza vaccination effectively prevents influenza-related hospitalizations in children aged ≤5 years. Besides, >7 h of sun exposure/week may also be associated with lower risk of influenza-related hospitalizations in children.
Copyright ? 2019. Published by Elsevier B.V.
[h=4]KEYWORDS:[/h] Hospitalization; Influenza; Sun exposure time; Vaccine effectiveness
PMID: 31732418 DOI: 10.1016/j.jmii.2019.09.010
Free full text