tetano
Editor, Senior Moderator
Sci Rep. 2018 Apr 24;8(1):6474. doi: 10.1038/s41598-018-24820-2.
[h=1]Effects of pre-existing orthopoxvirus-specific immunity on the performance of Modified Vaccinia virus Ankara-based influenza vaccines.[/h] Altenburg AF[SUP]1[/SUP], van Trierum SE[SUP]1[/SUP], de Bruin E[SUP]1[/SUP], de Meulder D[SUP]1[/SUP], van de Sandt CE[SUP]1[/SUP], van der Klis FRM[SUP]2[/SUP], Fouchier RAM[SUP]1[/SUP], Koopmans MPG[SUP]1[/SUP], Rimmelzwaan GF[SUP]1,[/SUP][SUP]3[/SUP], de Vries RD[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The replication-deficient orthopoxvirus modified vaccinia virus Ankara (MVA) is a promising vaccine vector against various pathogens and has an excellent safety record. However, pre-existing vector-specific immunity is frequently suggested to be a drawback of MVA-based vaccines. To address this issue, mice were vaccinated with MVA-based influenza vaccines in the presence or absence of orthopoxvirus-specific immunity. Importantly, protective efficacy of an MVA-based influenza vaccine against a homologous challenge was not impaired in the presence of orthopoxvirus-specific pre-existing immunity. Nonetheless, orthopoxvirus-specific pre-existing immunity reduced the induction of antigen-specific antibodies under specific conditions and completely prevented induction of antigen-specific T cell responses by rMVA-based vaccination. Notably, antibodies induced by vaccinia virus vaccination, both in mice and humans, were not capable of neutralizing MVA. Thus, when using rMVA-based vaccines it is important to consider the main correlate of protection induced by the vaccine, the vaccine dose and the orthopoxvirus immune status of vaccine recipients.
PMID: 29692427 DOI: 10.1038/s41598-018-24820-2
[h=1]Effects of pre-existing orthopoxvirus-specific immunity on the performance of Modified Vaccinia virus Ankara-based influenza vaccines.[/h] Altenburg AF[SUP]1[/SUP], van Trierum SE[SUP]1[/SUP], de Bruin E[SUP]1[/SUP], de Meulder D[SUP]1[/SUP], van de Sandt CE[SUP]1[/SUP], van der Klis FRM[SUP]2[/SUP], Fouchier RAM[SUP]1[/SUP], Koopmans MPG[SUP]1[/SUP], Rimmelzwaan GF[SUP]1,[/SUP][SUP]3[/SUP], de Vries RD[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The replication-deficient orthopoxvirus modified vaccinia virus Ankara (MVA) is a promising vaccine vector against various pathogens and has an excellent safety record. However, pre-existing vector-specific immunity is frequently suggested to be a drawback of MVA-based vaccines. To address this issue, mice were vaccinated with MVA-based influenza vaccines in the presence or absence of orthopoxvirus-specific immunity. Importantly, protective efficacy of an MVA-based influenza vaccine against a homologous challenge was not impaired in the presence of orthopoxvirus-specific pre-existing immunity. Nonetheless, orthopoxvirus-specific pre-existing immunity reduced the induction of antigen-specific antibodies under specific conditions and completely prevented induction of antigen-specific T cell responses by rMVA-based vaccination. Notably, antibodies induced by vaccinia virus vaccination, both in mice and humans, were not capable of neutralizing MVA. Thus, when using rMVA-based vaccines it is important to consider the main correlate of protection induced by the vaccine, the vaccine dose and the orthopoxvirus immune status of vaccine recipients.
PMID: 29692427 DOI: 10.1038/s41598-018-24820-2