tetano
Editor, Senior Moderator
J Virol. 2011 Jan 5. [Epub ahead of print]
Efficacy of vaccination with different combinations of MF59-adjuvanted and non-adjuvanted seasonal and pandemic influenza vaccines against pandemic H1N1 (2009) influenza in ferrets.
van den Brand JM, Kreijtz JH, Bodewes R, Stittelaar KJ, van Amerongen G, Kuiken T, Simon J, Fouchier RA, Del Giudice G, Rappuoli R, Rimmelzwaan GF, Osterhaus AD.
Department of Virology, Erasmus Medical Centre, Rotterdam, The Netherlands; ViroClinics Biosciences BV, Rotterdam, The Netherlands; Novartis Vaccines and Diagnostics, Siena, Italy.
Abstract
Serum antibodies induced by seasonal influenza or seasonal influenza vaccination exhibit limited or no cross-reactivity against the 2009 pandemic swine-origin influenza virus of the H1N1 subtype (pH1N1). Ferrets immunized once or twice with MF59-adjuvanted seasonal influenza vaccine exhibited significantly reduced lung virus titers but no substantial clinical protection against pH1N1 associated disease. However priming with MF59-adjuvanted seasonal influenza vaccine significantly increased the efficacy of a pandemic MF59-adjuvanted influenza vaccine against pH1N1 challenge. Elucidating the mechanism involved in this priming principle will contribute to our understanding of vaccine and infection induced correlates of protection. Furthermore a practical consequence of these findings is that during an emerging pandemic, the implementation of a priming strategy with an available adjuvanted seasonal vaccine to precede the eventual pandemic vaccination campaign, may be useful and life saving.
PMID: 21209108 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21209108
Efficacy of vaccination with different combinations of MF59-adjuvanted and non-adjuvanted seasonal and pandemic influenza vaccines against pandemic H1N1 (2009) influenza in ferrets.
van den Brand JM, Kreijtz JH, Bodewes R, Stittelaar KJ, van Amerongen G, Kuiken T, Simon J, Fouchier RA, Del Giudice G, Rappuoli R, Rimmelzwaan GF, Osterhaus AD.
Department of Virology, Erasmus Medical Centre, Rotterdam, The Netherlands; ViroClinics Biosciences BV, Rotterdam, The Netherlands; Novartis Vaccines and Diagnostics, Siena, Italy.
Abstract
Serum antibodies induced by seasonal influenza or seasonal influenza vaccination exhibit limited or no cross-reactivity against the 2009 pandemic swine-origin influenza virus of the H1N1 subtype (pH1N1). Ferrets immunized once or twice with MF59-adjuvanted seasonal influenza vaccine exhibited significantly reduced lung virus titers but no substantial clinical protection against pH1N1 associated disease. However priming with MF59-adjuvanted seasonal influenza vaccine significantly increased the efficacy of a pandemic MF59-adjuvanted influenza vaccine against pH1N1 challenge. Elucidating the mechanism involved in this priming principle will contribute to our understanding of vaccine and infection induced correlates of protection. Furthermore a practical consequence of these findings is that during an emerging pandemic, the implementation of a priming strategy with an available adjuvanted seasonal vaccine to precede the eventual pandemic vaccination campaign, may be useful and life saving.
PMID: 21209108 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21209108