tetano
Editor, Senior Moderator
Virology. 2014 Oct 25;471-473C:38-48. doi: 10.1016/j.virol.2014.10.002. [Epub ahead of print]
Efficient replication and strong induction of innate immune responses by H9N2 avian influenza virus in human dendritic cells.
Westenius V1, M?kel? SM2, Ziegler T3, Julkunen I4, Osterlund P2.
Author information
Abstract
Avian influenza A (H9N2) viruses have occasionally been identified in humans with upper respiratory tract infections. The novel H7N9/2013 virus identified in China shows that a low pathogenic avian influenza (LPAI) virus can be highly pathogenic in humans. Therefore, it is important to understand virus-host cell interactions and immune responses triggered by LPAI viruses in humans. We found that LPAI A/Hong Kong/1073/99 (H9N2) virus replicated efficiently in human dendritic cells (DCs). The H9N2 virus induced strong IFN gene expression although with different kinetics than seasonal influenza A/Beijing/353/89 (H3N2) virus. IFN inducible antiviral proteins were produced in H9N2 virus-infected cells at the same level as in H3N2 infection. The H9N2 virus was extremely sensitive to the antiviral actions of type I IFNs. These results indicate that the avian influenza H9N2 virus is inducing a strong antiviral IFN response in human DCs.
Copyright ? 2014 Elsevier Inc. All rights reserved.
KEYWORDS:
Avian influenza; Cytokine; Gene expression; H9N2 virus; IFNs; Innate immunity
PMID:
25461529
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25461529
Efficient replication and strong induction of innate immune responses by H9N2 avian influenza virus in human dendritic cells.
Westenius V1, M?kel? SM2, Ziegler T3, Julkunen I4, Osterlund P2.
Author information
Abstract
Avian influenza A (H9N2) viruses have occasionally been identified in humans with upper respiratory tract infections. The novel H7N9/2013 virus identified in China shows that a low pathogenic avian influenza (LPAI) virus can be highly pathogenic in humans. Therefore, it is important to understand virus-host cell interactions and immune responses triggered by LPAI viruses in humans. We found that LPAI A/Hong Kong/1073/99 (H9N2) virus replicated efficiently in human dendritic cells (DCs). The H9N2 virus induced strong IFN gene expression although with different kinetics than seasonal influenza A/Beijing/353/89 (H3N2) virus. IFN inducible antiviral proteins were produced in H9N2 virus-infected cells at the same level as in H3N2 infection. The H9N2 virus was extremely sensitive to the antiviral actions of type I IFNs. These results indicate that the avian influenza H9N2 virus is inducing a strong antiviral IFN response in human DCs.
Copyright ? 2014 Elsevier Inc. All rights reserved.
KEYWORDS:
Avian influenza; Cytokine; Gene expression; H9N2 virus; IFNs; Innate immunity
PMID:
25461529
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25461529